Treatment of intestinal ischemia with oxygenated intraluminal perfluorocarbons

Keith T. Oldham, Karen S. Guice, Dennis Gore, William K. Gourley, Thom E. Lobe

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Liquid perfluorocarbons are biologically inert compounds capable of dissolving up to 40 percent oxygen by volume. This remarkable and reversible oxygen solubility has encouraged investigations into therapeutic application in situations where tissue oxygen delivery is impaired. One such setting is intestinal ischemia. Identically prepared devascularized segments of rat intestine were treated with either intraluminal oxygenated perfluorocarbon (perfluorotributylamine) or physiologic saline solution. After timed sacrifice, blinded quantitative histologic evaluation for ischemic injury was performed. The perfluorotributylamine treatment groups had histologic scores indicative of less severe injury between 1 and 4 hours. These scores achieved statistical significance (p < 0.05). We conclude that intraluminal oxygenated perfluorocarbons have a significant protective effect in this model of intestinal ischemia. This quantitative analysis is unique and is an important aspect of the preclinical evaluation of the perfluorocarbon preparations.

Original languageEnglish (US)
Pages (from-to)291-294
Number of pages4
JournalThe American Journal of Surgery
Volume153
Issue number3
DOIs
StatePublished - 1987
Externally publishedYes

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Fluorocarbons
Ischemia
Oxygen
Wounds and Injuries
Sodium Chloride
Solubility
Intestines
perfluorotributylamine
Therapeutics

ASJC Scopus subject areas

  • Surgery

Cite this

Treatment of intestinal ischemia with oxygenated intraluminal perfluorocarbons. / Oldham, Keith T.; Guice, Karen S.; Gore, Dennis; Gourley, William K.; Lobe, Thom E.

In: The American Journal of Surgery, Vol. 153, No. 3, 1987, p. 291-294.

Research output: Contribution to journalArticle

Oldham, Keith T. ; Guice, Karen S. ; Gore, Dennis ; Gourley, William K. ; Lobe, Thom E. / Treatment of intestinal ischemia with oxygenated intraluminal perfluorocarbons. In: The American Journal of Surgery. 1987 ; Vol. 153, No. 3. pp. 291-294.
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