Treatment of Lassa virus infection in outbred guinea pigs with first-in-class human monoclonal antibodies

Robert W. Cross; Chad E. Mire; Luis M. Branco; Joan B. Geisbert; Megan M. Rowland; Megan L. Heinrich; Augustine Goba; Mambu Momoh; Donald S. Grant; Mohamed Fullah; Sheik Humarr Khan; James E. Robinson; Thomas W. Geisbert; Robert F. Garry

doi:10.1016/j.antiviral.2016.08.012

Treatment of Lassa virus infection in outbred guinea pigs with first-in-class human monoclonal antibodies

Robert W. Cross, Chad E. Mire, Luis M. Branco, Joan B. Geisbert, Megan M. Rowland, Megan L. Heinrich, Augustine Goba, Mambu Momoh, Donald S. Grant, Mohamed Fullah, Sheik Humarr Khan, James E. Robinson, Thomas W. Geisbert, Robert F. Garry

Microbiology And Immunology

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Lassa fever is a significant health threat to West African human populations with hundreds of thousands of annual cases. There are no approved medical countermeasures currently available. Compassionate use of the antiviral drug ribavirin or transfusion of convalescent serum has resulted in mixed success depending on when administered or the donor source, respectively. We previously identified several recombinant human monoclonal antibodies targeting the glycoprotein of Lassa virus with strong neutralization profiles in vitro. Here, we demonstrate remarkable therapeutic efficacy using first-in-class human antibodies in a guinea pig model of Lassa infection thereby presenting a promising treatment alternative.

Original language	English (US)
Pages (from-to)	218-222
Number of pages	5
Journal	Antiviral research
Volume	133
DOIs	https://doi.org/10.1016/j.antiviral.2016.08.012
State	Published - Sep 1 2016

ASJC Scopus subject areas

Pharmacology
Virology

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10.1016/j.antiviral.2016.08.012

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Cross, R. W., Mire, C. E., Branco, L. M., Geisbert, J. B., Rowland, M. M., Heinrich, M. L., Goba, A., Momoh, M., Grant, D. S., Fullah, M., Khan, S. H., Robinson, J. E., Geisbert, T. W., & Garry, R. F. (2016). Treatment of Lassa virus infection in outbred guinea pigs with first-in-class human monoclonal antibodies. Antiviral research, 133, 218-222. https://doi.org/10.1016/j.antiviral.2016.08.012

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title = "Treatment of Lassa virus infection in outbred guinea pigs with first-in-class human monoclonal antibodies",

abstract = "Lassa fever is a significant health threat to West African human populations with hundreds of thousands of annual cases. There are no approved medical countermeasures currently available. Compassionate use of the antiviral drug ribavirin or transfusion of convalescent serum has resulted in mixed success depending on when administered or the donor source, respectively. We previously identified several recombinant human monoclonal antibodies targeting the glycoprotein of Lassa virus with strong neutralization profiles in vitro. Here, we demonstrate remarkable therapeutic efficacy using first-in-class human antibodies in a guinea pig model of Lassa infection thereby presenting a promising treatment alternative.",

author = "Cross, {Robert W.} and Mire, {Chad E.} and Branco, {Luis M.} and Geisbert, {Joan B.} and Rowland, {Megan M.} and Heinrich, {Megan L.} and Augustine Goba and Mambu Momoh and Grant, {Donald S.} and Mohamed Fullah and Khan, {Sheik Humarr} and Robinson, {James E.} and Geisbert, {Thomas W.} and Garry, {Robert F.}",

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AU - Cross, Robert W.

AU - Mire, Chad E.

AU - Branco, Luis M.

AU - Geisbert, Joan B.

AU - Rowland, Megan M.

AU - Heinrich, Megan L.

AU - Goba, Augustine

AU - Momoh, Mambu

AU - Grant, Donald S.

AU - Fullah, Mohamed

AU - Khan, Sheik Humarr

AU - Robinson, James E.

AU - Geisbert, Thomas W.

AU - Garry, Robert F.

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AB - Lassa fever is a significant health threat to West African human populations with hundreds of thousands of annual cases. There are no approved medical countermeasures currently available. Compassionate use of the antiviral drug ribavirin or transfusion of convalescent serum has resulted in mixed success depending on when administered or the donor source, respectively. We previously identified several recombinant human monoclonal antibodies targeting the glycoprotein of Lassa virus with strong neutralization profiles in vitro. Here, we demonstrate remarkable therapeutic efficacy using first-in-class human antibodies in a guinea pig model of Lassa infection thereby presenting a promising treatment alternative.

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Treatment of Lassa virus infection in outbred guinea pigs with first-in-class human monoclonal antibodies

Abstract

ASJC Scopus subject areas

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