Treatment of Lassa virus infection in outbred guinea pigs with first-in-class human monoclonal antibodies

Robert Cross, Chad Mire, Luis M. Branco, Joan B. Geisbert, Megan M. Rowland, Megan L. Heinrich, Augustine Goba, Mambu Momoh, Donald S. Grant, Mohamed Fullah, Sheik Humarr Khan, James E. Robinson, Thomas Geisbert, Robert F. Garry

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Lassa fever is a significant health threat to West African human populations with hundreds of thousands of annual cases. There are no approved medical countermeasures currently available. Compassionate use of the antiviral drug ribavirin or transfusion of convalescent serum has resulted in mixed success depending on when administered or the donor source, respectively. We previously identified several recombinant human monoclonal antibodies targeting the glycoprotein of Lassa virus with strong neutralization profiles in vitro. Here, we demonstrate remarkable therapeutic efficacy using first-in-class human antibodies in a guinea pig model of Lassa infection thereby presenting a promising treatment alternative.

Original languageEnglish (US)
Pages (from-to)218-222
Number of pages5
JournalAntiviral Research
Volume133
DOIs
StatePublished - Sep 1 2016

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Lassa virus
Virus Diseases
Guinea Pigs
Monoclonal Antibodies
Lassa Fever
Compassionate Use Trials
Immunoglobulin Isotypes
Ribavirin
Antiviral Agents
Glycoproteins
Therapeutics
Health
Infection
Serum
Population

ASJC Scopus subject areas

  • Pharmacology
  • Virology

Cite this

Treatment of Lassa virus infection in outbred guinea pigs with first-in-class human monoclonal antibodies. / Cross, Robert; Mire, Chad; Branco, Luis M.; Geisbert, Joan B.; Rowland, Megan M.; Heinrich, Megan L.; Goba, Augustine; Momoh, Mambu; Grant, Donald S.; Fullah, Mohamed; Khan, Sheik Humarr; Robinson, James E.; Geisbert, Thomas; Garry, Robert F.

In: Antiviral Research, Vol. 133, 01.09.2016, p. 218-222.

Research output: Contribution to journalArticle

Cross, R, Mire, C, Branco, LM, Geisbert, JB, Rowland, MM, Heinrich, ML, Goba, A, Momoh, M, Grant, DS, Fullah, M, Khan, SH, Robinson, JE, Geisbert, T & Garry, RF 2016, 'Treatment of Lassa virus infection in outbred guinea pigs with first-in-class human monoclonal antibodies', Antiviral Research, vol. 133, pp. 218-222. https://doi.org/10.1016/j.antiviral.2016.08.012
Cross, Robert ; Mire, Chad ; Branco, Luis M. ; Geisbert, Joan B. ; Rowland, Megan M. ; Heinrich, Megan L. ; Goba, Augustine ; Momoh, Mambu ; Grant, Donald S. ; Fullah, Mohamed ; Khan, Sheik Humarr ; Robinson, James E. ; Geisbert, Thomas ; Garry, Robert F. / Treatment of Lassa virus infection in outbred guinea pigs with first-in-class human monoclonal antibodies. In: Antiviral Research. 2016 ; Vol. 133. pp. 218-222.
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