Treatment of neurocysticercosis: Current status and future research needs

T. E. Nash, G. Singh, A. C. White, V. Rajshekhar, J. A. Loeb, J. V. Proaño, O. M. Takayanagui, A. E. Gonzalez, J. A. Butman, C. DeGiorgio, O. H. Del Brutto, A. Delgado-Escueta, C. A.W. Evans, R. H. Gilman, S. M. Martinez, M. T. Medina, E. J. Pretell, J. Teale, H. H. Garcia

Research output: Contribution to journalReview article

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Abstract

Here we put forward a roadmap that summarizes important questions that need to be answered to determine more effective and safer treatments. A key concept in management of neurocysticercosis is the understanding that infection and disease due to neurocysticercosis are variable and thus different clinical approaches and treatments are required. Despite recent advances, treatments remain either suboptimal or based on poorly controlled or anecdotal experience. A better understanding of basic pathophysiologic mechanisms including parasite survival and evolution, nature of the inflammatory response, and the genesis of seizures, epilepsy, and mechanisms of anthelmintic action should lead to improved therapies.

Original languageEnglish (US)
Pages (from-to)1120-1127
Number of pages8
JournalNeurology
Volume67
Issue number7
DOIs
StatePublished - Oct 1 2006
Externally publishedYes

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ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Nash, T. E., Singh, G., White, A. C., Rajshekhar, V., Loeb, J. A., Proaño, J. V., Takayanagui, O. M., Gonzalez, A. E., Butman, J. A., DeGiorgio, C., Del Brutto, O. H., Delgado-Escueta, A., Evans, C. A. W., Gilman, R. H., Martinez, S. M., Medina, M. T., Pretell, E. J., Teale, J., & Garcia, H. H. (2006). Treatment of neurocysticercosis: Current status and future research needs. Neurology, 67(7), 1120-1127. https://doi.org/10.1212/01.wnl.0000238514.51747.3a