Treatment of second degree facial burns with allografts - Preliminary results

Raymund E. Horch, Marc G. Jeschke, Gerald Spilker, David N. Herndon, Jürgen Kopp

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

Facial burns are very common and have significant clinical impact. However, the treatment regimen for superficial to deep facial burns is not well defined. The purpose of this study was to investigate the effects of cadaver skin grafting in deep partial thickness facial burns in comparison to standard care. In a prospective open study design severely injured patients with superficial and deep partial thickness burns were randomized into the group receiving open treatment with silversulfadiazine (standard n = 5) or into the group receiving early superficial debridement followed by coverage with glycerolized cadaver skin (n = 5). The outcome measures were time and quality of wound healing, and incidence of hypertrophic scarring at 3 and 6 months post burn. There were no significant differences in demographics between groups. In the group treated with the allogenic material time to reepithelialization was 10.5 days, while it was 12.4 days in the silversulfadiazine group (p < 0.05). Scar quality was found to be significantly improved in the allogenic treatment group. Three and 6 months postburn there were no patients with significant hypertrophic scarring in the allogenic group while there were two patients who developed hypertrophic scars in the silversulfadiazine group (p < 0.05). In this study, we demonstrated that glyzerolized cadaver allograft skin represents a superior biological dressing for shallow and deep partial thickness facial burns. This is in concordance with other reports on scalds. It would be worthwhile to perform more clinical studies with a larger number of patients to further evaluate the effect and function of allogenic skin for facial burns.

Original languageEnglish (US)
Pages (from-to)597-602
Number of pages6
JournalBurns
Volume31
Issue number5
DOIs
StatePublished - Aug 1 2005

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Keywords

  • Allograft
  • Facial burns
  • Scar quality

ASJC Scopus subject areas

  • Surgery
  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Horch, R. E., Jeschke, M. G., Spilker, G., Herndon, D. N., & Kopp, J. (2005). Treatment of second degree facial burns with allografts - Preliminary results. Burns, 31(5), 597-602. https://doi.org/10.1016/j.burns.2005.01.011