Abstract
Systemic treatment with the N-methyl-d-aspartate (NMDA) antagonist memantine (MEM) resulted in a decrease in mechanical hyperalgesia and mechanical allodynia in neuropathic rats. Bolus injections of 5, 10 and 20 mg/kg MEM (i.p.) attenuated withdrawal responses following mechanical stimulation for up to 6 h post-injection while saline had no effect. A more remarkable effect was observed following chronic treatment with MEM via mini-osmotic pumps (8 mg/kg per h for 7 days, i.p.), in which nociceptive responses were decreased during treatment and remained depressed for 3 days post-treatment. These antinociceptive effects can be obtained at doses which do not produce motor dysfunction. The results of this study demonstrate that MEM has a therapeutic effect on mechanical hyperalgesia and allodynia and may be considered as an alternative treatment for pathological pain in the clinical setting.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 115-118 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 198 |
| Issue number | 2 |
| DOIs | |
| State | Published - Sep 29 1995 |
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Keywords
- Mechanical allodynia
- Mechanical hyperalgesia
- Nociception
- Peripheral nerve injury
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Treatment with the NMDA antagonist memantine attenuates nociceptive responses to mechanical stimulation in neuropathic rats. / Carlton, Susan M.; Hargett, Gregory L.
In: Neuroscience Letters, Vol. 198, No. 2, 29.09.1995, p. 115-118.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Treatment with the NMDA antagonist memantine attenuates nociceptive responses to mechanical stimulation in neuropathic rats
AU - Carlton, Susan M.
AU - Hargett, Gregory L.
PY - 1995/9/29
Y1 - 1995/9/29
N2 - Systemic treatment with the N-methyl-d-aspartate (NMDA) antagonist memantine (MEM) resulted in a decrease in mechanical hyperalgesia and mechanical allodynia in neuropathic rats. Bolus injections of 5, 10 and 20 mg/kg MEM (i.p.) attenuated withdrawal responses following mechanical stimulation for up to 6 h post-injection while saline had no effect. A more remarkable effect was observed following chronic treatment with MEM via mini-osmotic pumps (8 mg/kg per h for 7 days, i.p.), in which nociceptive responses were decreased during treatment and remained depressed for 3 days post-treatment. These antinociceptive effects can be obtained at doses which do not produce motor dysfunction. The results of this study demonstrate that MEM has a therapeutic effect on mechanical hyperalgesia and allodynia and may be considered as an alternative treatment for pathological pain in the clinical setting.
AB - Systemic treatment with the N-methyl-d-aspartate (NMDA) antagonist memantine (MEM) resulted in a decrease in mechanical hyperalgesia and mechanical allodynia in neuropathic rats. Bolus injections of 5, 10 and 20 mg/kg MEM (i.p.) attenuated withdrawal responses following mechanical stimulation for up to 6 h post-injection while saline had no effect. A more remarkable effect was observed following chronic treatment with MEM via mini-osmotic pumps (8 mg/kg per h for 7 days, i.p.), in which nociceptive responses were decreased during treatment and remained depressed for 3 days post-treatment. These antinociceptive effects can be obtained at doses which do not produce motor dysfunction. The results of this study demonstrate that MEM has a therapeutic effect on mechanical hyperalgesia and allodynia and may be considered as an alternative treatment for pathological pain in the clinical setting.
KW - Mechanical allodynia
KW - Mechanical hyperalgesia
KW - Nociception
KW - Peripheral nerve injury
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U2 - 10.1016/0304-3940(95)11980-B
DO - 10.1016/0304-3940(95)11980-B
M3 - Article
VL - 198
SP - 115
EP - 118
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 2
ER -