Trends in Endometrial Cancer Incidence Among Premenopausal and Postmenopausal Women in the United States Between 2001 and 2021

The aim of this study was to assess endometrial cancer incidence in both premenopausal and postmenopausal women in the US from 2001 to 2021 using data for US adult females from the United States Cancer Statistics 2001–2021 database. From 2001 to 2021, endometrial cancer incidence increased in those aged 20–49 years and in those aged 70+ years. Endometrial cancer incidence has decreased in recent years (from 2016 to 2021) among adults aged 50–69 years. The incidence rate of endometrial cancer sharply decreased from 2019 to 2020 in all age groups, and the proportion of metastatic cancer increased across all age groups. In 2021, the incidence returned to 2019 levels. In conclusion, there were increasing trends in endometrial cancer among premenopausal women between 2001 and 2021. During the beginning of the COVID-19 pandemic, the incidence rates decreased, but the proportion of metastatic cancer increased.