TY - JOUR
T1 - Trends in the inpatient burden of coronary artery disease in granulomatosis with polyangiitis
T2 - A study of a large national dataset
AU - Luo, Yiming
AU - Xu, Jiehui
AU - Jiang, Changchuan
AU - Krittanawong, Chayakrit
AU - Wu, Lingling
AU - Yang, Yifeng
AU - Bandyopadhyay, Dhrubajyoti
AU - Cram, Peter
AU - Ibrahim, Said
AU - Mehta, Bella
N1 - Publisher Copyright:
© 2021 Journal of Rheumatology. All rights reserved.
PY - 2021/4/1
Y1 - 2021/4/1
N2 - Objective. Cardiovascular (CV) diseases are serious comorbidities in patients with granulomatosis with polyangiitis (GPA). In a sample of patients hospitalized for GPA, we sought to examine trends in the burden of coronary artery disease (CAD) and its 2 serious manifestations, acute myocardial infarction (AMI) and heart failure (HF). Methods. We used the National Inpatient Sample to conduct a retrospective cross-sectional analysis. Our sample consisted of hospitalizations for GPA between 2005 and 2014. We examined trends in the proportion of CAD, AMI, and HF in all hospitalizations with GPA compared to those without GPA. We used logistic regression adjusted for potential confounders and included interaction terms. Results. Among a total of 103,453 GPA hospitalizations, 20,351 (19.7%) hospitalizations had a concurrent diagnosis of CAD. GPA with CAD was associated with overall lower burden of traditional CV risk factors compared to non-GPA with CAD, with the exception of chronic kidney disease (57% vs 21%). Over the 10-year study period, there were rising trends in the inpatient burden of CAD (16.6% in 2005 to 22.7% in 2014) and CAD with HF (4.3% in 2005 to 9.9% in 2014), but not AMI (1.2% in 2005 to 1.1% in 2014), in GPA hospitalizations compared to non-GPA controls. Conclusion. In this national sample of GPA hospitalizations, we found that the burden of CAD and CAD with HF was on the rise over the 10-year period compared to non-GPA; however, it was not the case for AMI.
AB - Objective. Cardiovascular (CV) diseases are serious comorbidities in patients with granulomatosis with polyangiitis (GPA). In a sample of patients hospitalized for GPA, we sought to examine trends in the burden of coronary artery disease (CAD) and its 2 serious manifestations, acute myocardial infarction (AMI) and heart failure (HF). Methods. We used the National Inpatient Sample to conduct a retrospective cross-sectional analysis. Our sample consisted of hospitalizations for GPA between 2005 and 2014. We examined trends in the proportion of CAD, AMI, and HF in all hospitalizations with GPA compared to those without GPA. We used logistic regression adjusted for potential confounders and included interaction terms. Results. Among a total of 103,453 GPA hospitalizations, 20,351 (19.7%) hospitalizations had a concurrent diagnosis of CAD. GPA with CAD was associated with overall lower burden of traditional CV risk factors compared to non-GPA with CAD, with the exception of chronic kidney disease (57% vs 21%). Over the 10-year study period, there were rising trends in the inpatient burden of CAD (16.6% in 2005 to 22.7% in 2014) and CAD with HF (4.3% in 2005 to 9.9% in 2014), but not AMI (1.2% in 2005 to 1.1% in 2014), in GPA hospitalizations compared to non-GPA controls. Conclusion. In this national sample of GPA hospitalizations, we found that the burden of CAD and CAD with HF was on the rise over the 10-year period compared to non-GPA; however, it was not the case for AMI.
KW - Coronary artery disease
KW - Epidemiology
KW - Granulomatosis with polyangiitis
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U2 - 10.3899/JRHEUM.200374
DO - 10.3899/JRHEUM.200374
M3 - Article
C2 - 32541074
AN - SCOPUS:85089996792
SN - 0315-162X
VL - 48
SP - 548
EP - 554
JO - Journal of Rheumatology
JF - Journal of Rheumatology
IS - 4
ER -