Tricyclic indole and dihydroindole derivatives as new inhibitors of soluble guanylate cyclase

Katerina Spyridonidou; Manolis Fousteris; Marazioti Antonia; Athanasia Chatzianastasiou; Andreas Papapetropoulos; Sotiris Nikolaropoulos

doi:10.1016/j.bmcl.2009.06.047

Tricyclic indole and dihydroindole derivatives as new inhibitors of soluble guanylate cyclase

Katerina Spyridonidou, Manolis Fousteris, Marazioti Antonia, Athanasia Chatzianastasiou, Andreas Papapetropoulos, Sotiris Nikolaropoulos

Research output: Contribution to journal › Article

12 Scopus citations

Abstract

The synthesis of new tricyclic fused indole and dihydroindole derivatives and preliminary results from their in vitro inhibitory activity against soluble guanylate cyclase (sGC) are presented.

Original language	English (US)
Pages (from-to)	4810-4813
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	16
DOIs	https://doi.org/10.1016/j.bmcl.2009.06.047
State	Published - Aug 15 2009
Externally published	Yes

Keywords

cGMP
Indole derivatives
ODQ analogues
Soluble guanylate cyclase

ASJC Scopus subject areas

Pharmaceutical Science
Drug Discovery
Organic Chemistry
Molecular Medicine
Molecular Biology
Clinical Biochemistry
Biochemistry

Access to Document

10.1016/j.bmcl.2009.06.047

Fingerprint Dive into the research topics of 'Tricyclic indole and dihydroindole derivatives as new inhibitors of soluble guanylate cyclase'. Together they form a unique fingerprint.

Cite this

Spyridonidou, K., Fousteris, M., Antonia, M., Chatzianastasiou, A., Papapetropoulos, A., & Nikolaropoulos, S. (2009). Tricyclic indole and dihydroindole derivatives as new inhibitors of soluble guanylate cyclase. Bioorganic and Medicinal Chemistry Letters, 19(16), 4810-4813. https://doi.org/10.1016/j.bmcl.2009.06.047

Tricyclic indole and dihydroindole derivatives as new inhibitors of soluble guanylate cyclase. / Spyridonidou, Katerina; Fousteris, Manolis; Antonia, Marazioti; Chatzianastasiou, Athanasia; Papapetropoulos, Andreas; Nikolaropoulos, Sotiris.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 19, No. 16, 15.08.2009, p. 4810-4813.

Research output: Contribution to journal › Article

@article{501f1e4722b44deaab0c38698893e8c5,

title = "Tricyclic indole and dihydroindole derivatives as new inhibitors of soluble guanylate cyclase",

abstract = "The synthesis of new tricyclic fused indole and dihydroindole derivatives and preliminary results from their in vitro inhibitory activity against soluble guanylate cyclase (sGC) are presented.",

keywords = "cGMP, Indole derivatives, ODQ analogues, Soluble guanylate cyclase",

author = "Katerina Spyridonidou and Manolis Fousteris and Marazioti Antonia and Athanasia Chatzianastasiou and Andreas Papapetropoulos and Sotiris Nikolaropoulos",

year = "2009",

month = aug,

day = "15",

doi = "10.1016/j.bmcl.2009.06.047",

language = "English (US)",

volume = "19",

pages = "4810--4813",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "16",

}

TY - JOUR

T1 - Tricyclic indole and dihydroindole derivatives as new inhibitors of soluble guanylate cyclase

AU - Spyridonidou, Katerina

AU - Fousteris, Manolis

AU - Antonia, Marazioti

AU - Chatzianastasiou, Athanasia

AU - Papapetropoulos, Andreas

AU - Nikolaropoulos, Sotiris

PY - 2009/8/15

Y1 - 2009/8/15

N2 - The synthesis of new tricyclic fused indole and dihydroindole derivatives and preliminary results from their in vitro inhibitory activity against soluble guanylate cyclase (sGC) are presented.

AB - The synthesis of new tricyclic fused indole and dihydroindole derivatives and preliminary results from their in vitro inhibitory activity against soluble guanylate cyclase (sGC) are presented.

KW - cGMP

KW - Indole derivatives

KW - ODQ analogues

KW - Soluble guanylate cyclase

UR - http://www.scopus.com/inward/record.url?scp=67651102829&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67651102829&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2009.06.047

DO - 10.1016/j.bmcl.2009.06.047

M3 - Article

C2 - 19560917

AN - SCOPUS:67651102829

VL - 19

SP - 4810

EP - 4813

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 16

ER -