Tricyclic indole and dihydroindole derivatives as new inhibitors of soluble guanylate cyclase

Katerina Spyridonidou; Manolis Fousteris; Marazioti Antonia; Athanasia Chatzianastasiou; Andreas Papapetropoulos; Sotiris Nikolaropoulos

doi:10.1016/j.bmcl.2009.06.047

Tricyclic indole and dihydroindole derivatives as new inhibitors of soluble guanylate cyclase

Katerina Spyridonidou, Manolis Fousteris, Marazioti Antonia, Athanasia Chatzianastasiou, Andreas Papapetropoulos, Sotiris Nikolaropoulos

Research output: Contribution to journal › Article

13 Scopus citations

Abstract

The synthesis of new tricyclic fused indole and dihydroindole derivatives and preliminary results from their in vitro inhibitory activity against soluble guanylate cyclase (sGC) are presented.

Original language	English (US)
Pages (from-to)	4810-4813
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	16
DOIs	https://doi.org/10.1016/j.bmcl.2009.06.047
State	Published - Aug 15 2009
Externally published	Yes

Keywords

cGMP
Indole derivatives
ODQ analogues
Soluble guanylate cyclase

ASJC Scopus subject areas

Pharmaceutical Science
Drug Discovery
Organic Chemistry
Molecular Medicine
Molecular Biology
Clinical Biochemistry
Biochemistry

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Spyridonidou, K., Fousteris, M., Antonia, M., Chatzianastasiou, A., Papapetropoulos, A., & Nikolaropoulos, S. (2009). Tricyclic indole and dihydroindole derivatives as new inhibitors of soluble guanylate cyclase. Bioorganic and Medicinal Chemistry Letters, 19(16), 4810-4813. https://doi.org/10.1016/j.bmcl.2009.06.047

Tricyclic indole and dihydroindole derivatives as new inhibitors of soluble guanylate cyclase. / Spyridonidou, Katerina; Fousteris, Manolis; Antonia, Marazioti; Chatzianastasiou, Athanasia; Papapetropoulos, Andreas; Nikolaropoulos, Sotiris.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 19, No. 16, 15.08.2009, p. 4810-4813.

Research output: Contribution to journal › Article

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