Abstract
The synthesis of new tricyclic fused indole and dihydroindole derivatives and preliminary results from their in vitro inhibitory activity against soluble guanylate cyclase (sGC) are presented.
Original language | English (US) |
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Pages (from-to) | 4810-4813 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 19 |
Issue number | 16 |
DOIs | |
State | Published - Aug 15 2009 |
Externally published | Yes |
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Keywords
- cGMP
- Indole derivatives
- ODQ analogues
- Soluble guanylate cyclase
ASJC Scopus subject areas
- Pharmaceutical Science
- Drug Discovery
- Organic Chemistry
- Molecular Medicine
- Molecular Biology
- Clinical Biochemistry
- Biochemistry
Cite this
Tricyclic indole and dihydroindole derivatives as new inhibitors of soluble guanylate cyclase. / Spyridonidou, Katerina; Fousteris, Manolis; Antonia, Marazioti; Chatzianastasiou, Athanasia; Papapetropoulos, Andreas; Nikolaropoulos, Sotiris.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 19, No. 16, 15.08.2009, p. 4810-4813.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tricyclic indole and dihydroindole derivatives as new inhibitors of soluble guanylate cyclase
AU - Spyridonidou, Katerina
AU - Fousteris, Manolis
AU - Antonia, Marazioti
AU - Chatzianastasiou, Athanasia
AU - Papapetropoulos, Andreas
AU - Nikolaropoulos, Sotiris
PY - 2009/8/15
Y1 - 2009/8/15
N2 - The synthesis of new tricyclic fused indole and dihydroindole derivatives and preliminary results from their in vitro inhibitory activity against soluble guanylate cyclase (sGC) are presented.
AB - The synthesis of new tricyclic fused indole and dihydroindole derivatives and preliminary results from their in vitro inhibitory activity against soluble guanylate cyclase (sGC) are presented.
KW - cGMP
KW - Indole derivatives
KW - ODQ analogues
KW - Soluble guanylate cyclase
UR - http://www.scopus.com/inward/record.url?scp=67651102829&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67651102829&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2009.06.047
DO - 10.1016/j.bmcl.2009.06.047
M3 - Article
C2 - 19560917
AN - SCOPUS:67651102829
VL - 19
SP - 4810
EP - 4813
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 16
ER -