Tricyclic indole and dihydroindole derivatives as new inhibitors of soluble guanylate cyclase

Katerina Spyridonidou, Manolis Fousteris, Marazioti Antonia, Athanasia Chatzianastasiou, Andreas Papapetropoulos, Sotiris Nikolaropoulos

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The synthesis of new tricyclic fused indole and dihydroindole derivatives and preliminary results from their in vitro inhibitory activity against soluble guanylate cyclase (sGC) are presented.

Original languageEnglish (US)
Pages (from-to)4810-4813
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number16
DOIs
StatePublished - Aug 15 2009
Externally publishedYes

Keywords

  • cGMP
  • Indole derivatives
  • ODQ analogues
  • Soluble guanylate cyclase

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

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