Tricyclic indole and dihydroindole derivatives as new inhibitors of soluble guanylate cyclase

Katerina Spyridonidou; Manolis Fousteris; Marazioti Antonia; Athanasia Chatzianastasiou; Andreas Papapetropoulos; Sotiris Nikolaropoulos

doi:10.1016/j.bmcl.2009.06.047

Tricyclic indole and dihydroindole derivatives as new inhibitors of soluble guanylate cyclase

Katerina Spyridonidou
, Manolis Fousteris
, Marazioti Antonia
, Athanasia Chatzianastasiou
, Andreas Papapetropoulos
, Sotiris Nikolaropoulos

Surgery

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The synthesis of new tricyclic fused indole and dihydroindole derivatives and preliminary results from their in vitro inhibitory activity against soluble guanylate cyclase (sGC) are presented.

Original language	English (US)
Pages (from-to)	4810-4813
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	16
DOIs	https://doi.org/10.1016/j.bmcl.2009.06.047
State	Published - Aug 15 2009

Keywords

Indole derivatives
ODQ analogues
Soluble guanylate cyclase
cGMP

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2009.06.047

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title = "Tricyclic indole and dihydroindole derivatives as new inhibitors of soluble guanylate cyclase",

abstract = "The synthesis of new tricyclic fused indole and dihydroindole derivatives and preliminary results from their in vitro inhibitory activity against soluble guanylate cyclase (sGC) are presented.",

keywords = "Indole derivatives, ODQ analogues, Soluble guanylate cyclase, cGMP",

author = "Katerina Spyridonidou and Manolis Fousteris and Marazioti Antonia and Athanasia Chatzianastasiou and Andreas Papapetropoulos and Sotiris Nikolaropoulos",

note = "Funding Information: This Letter is part of the 03ED375 research project, implemented within the framework of the {\textquoteleft}Reinforcement Programme of Human Research Manpower{\textquoteright} (PENED) and co-financed by National and Community Funds (20\% from the Greek Ministry of Development-General Secretariat of Research and Technology and 80\% from E.U.-European Social Fund). ",

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T1 - Tricyclic indole and dihydroindole derivatives as new inhibitors of soluble guanylate cyclase

AU - Spyridonidou, Katerina

AU - Fousteris, Manolis

AU - Antonia, Marazioti

AU - Chatzianastasiou, Athanasia

AU - Papapetropoulos, Andreas

AU - Nikolaropoulos, Sotiris

N1 - Funding Information: This Letter is part of the 03ED375 research project, implemented within the framework of the ‘Reinforcement Programme of Human Research Manpower’ (PENED) and co-financed by National and Community Funds (20% from the Greek Ministry of Development-General Secretariat of Research and Technology and 80% from E.U.-European Social Fund).

PY - 2009/8/15

Y1 - 2009/8/15

N2 - The synthesis of new tricyclic fused indole and dihydroindole derivatives and preliminary results from their in vitro inhibitory activity against soluble guanylate cyclase (sGC) are presented.

AB - The synthesis of new tricyclic fused indole and dihydroindole derivatives and preliminary results from their in vitro inhibitory activity against soluble guanylate cyclase (sGC) are presented.

KW - Indole derivatives

KW - ODQ analogues

KW - Soluble guanylate cyclase

KW - cGMP

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UR - https://www.scopus.com/pages/publications/67651102829#tab=citedBy

U2 - 10.1016/j.bmcl.2009.06.047

DO - 10.1016/j.bmcl.2009.06.047

M3 - Article

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AN - SCOPUS:67651102829

SN - 0960-894X

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EP - 4813

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 16

ER -

Tricyclic indole and dihydroindole derivatives as new inhibitors of soluble guanylate cyclase

Abstract

Keywords

ASJC Scopus subject areas

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