Tripartite-motif proteins and innate immune regulation

Finlay W. McNab; Ricardo Rajsbaum; Jonathan P. Stoye; Anne O'Garra

doi:10.1016/j.coi.2010.10.021

Tripartite-motif proteins and innate immune regulation

Finlay W. McNab, Ricardo Rajsbaum, Jonathan P. Stoye, Anne O'Garra

Research output: Contribution to journal › Review article › peer-review

215 Scopus citations

Abstract

The tripartite motif containing (TRIM) proteins are a family of proteins that have been implicated in many biological processes including cell differentiation, apoptosis, transcriptional regulation and signaling pathways. Many TRIM proteins are upregulated by the immunologically important Type I and Type II interferons and several, including TRIM5α and TRIM19/PML, restrict viral replication. There is growing evidence that TRIMs also play an important role in the broader immune response through regulating signaling pathways such as the RIG-I pathway. In this review we discuss recent research elucidating TRIM regulation of a number of pathways important in immunity and review the latest findings relating to viral restriction by TRIMs.

Original language	English (US)
Pages (from-to)	46-56
Number of pages	11
Journal	Current Opinion in Immunology
Volume	23
Issue number	1
DOIs	https://doi.org/10.1016/j.coi.2010.10.021
State	Published - Feb 2011
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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title = "Tripartite-motif proteins and innate immune regulation",

abstract = "The tripartite motif containing (TRIM) proteins are a family of proteins that have been implicated in many biological processes including cell differentiation, apoptosis, transcriptional regulation and signaling pathways. Many TRIM proteins are upregulated by the immunologically important Type I and Type II interferons and several, including TRIM5α and TRIM19/PML, restrict viral replication. There is growing evidence that TRIMs also play an important role in the broader immune response through regulating signaling pathways such as the RIG-I pathway. In this review we discuss recent research elucidating TRIM regulation of a number of pathways important in immunity and review the latest findings relating to viral restriction by TRIMs.",

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AU - Rajsbaum, Ricardo

AU - Stoye, Jonathan P.

AU - O'Garra, Anne

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AB - The tripartite motif containing (TRIM) proteins are a family of proteins that have been implicated in many biological processes including cell differentiation, apoptosis, transcriptional regulation and signaling pathways. Many TRIM proteins are upregulated by the immunologically important Type I and Type II interferons and several, including TRIM5α and TRIM19/PML, restrict viral replication. There is growing evidence that TRIMs also play an important role in the broader immune response through regulating signaling pathways such as the RIG-I pathway. In this review we discuss recent research elucidating TRIM regulation of a number of pathways important in immunity and review the latest findings relating to viral restriction by TRIMs.

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Tripartite-motif proteins and innate immune regulation

Abstract

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