Tripartite-motif proteins and innate immune regulation

Finlay W. McNab, Ricardo Rajsbaum, Jonathan P. Stoye, Anne O'Garra

Research output: Contribution to journalReview article

158 Scopus citations

Abstract

The tripartite motif containing (TRIM) proteins are a family of proteins that have been implicated in many biological processes including cell differentiation, apoptosis, transcriptional regulation and signaling pathways. Many TRIM proteins are upregulated by the immunologically important Type I and Type II interferons and several, including TRIM5α and TRIM19/PML, restrict viral replication. There is growing evidence that TRIMs also play an important role in the broader immune response through regulating signaling pathways such as the RIG-I pathway. In this review we discuss recent research elucidating TRIM regulation of a number of pathways important in immunity and review the latest findings relating to viral restriction by TRIMs.

Original languageEnglish (US)
Pages (from-to)46-56
Number of pages11
JournalCurrent Opinion in Immunology
Volume23
Issue number1
DOIs
StatePublished - Feb 1 2011
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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