Tropisetron increases the inhibitory effect of mild restraint on lordosis behavior of hormonally primed, ovariectomized rats

Lynda Uphouse, Danyeal Heckard, Cindy Hiegel, Jutatip Guptarak, Sharmin Maswood

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Ovariectomized rats, hormonally primed with 10μg estradiol benzoate and 500μg progesterone are resistant to the lordosis-inhibiting effects of a 5min restraint experience. However, modulation of the serotonergic (5-HT) system alters this resistance to stress. In the following experiment, ovariectomized Fischer inbred rats were hormonally primed with 10μg estradiol benzoate and 500μg progesterone. The effect of 5min restraint on sexual behavior was examined after bilateral hypothalamic infusion or intraperitoneal (ip) treatment with the 5-HT 3 receptor antagonist, 3-tropanylindole-3-carboxylate hydrochloride (tropisetron). Infusion with 50 or 100ng tropisetron inhibited lordosis behavior. When rats were infused with 10 or 25ng tropisetron, rats showed normal lordosis behavior. However, when infusion with 10 or 25ng tropisetron was combined with 5min restraint, lordosis behavior was inhibited. These findings are consistent with prior work that has implicated hypothalamic serotonin in control of lordosis behavior and in the effect of mild restraint on the behavior. In contrast to the effects of the intracranial infusion, intraperitoneal injection with 1.0 or 2.0mg/kg tropisetron did not amplify the effects of restraint.

Original languageEnglish (US)
Pages (from-to)221-226
Number of pages6
JournalBehavioural Brain Research
Volume219
Issue number2
DOIs
StatePublished - Jun 1 2011
Externally publishedYes

Fingerprint

tropisetron
Lordosis
Serotonin
Parenteral Infusions
Behavior Control
Serotonin Receptors
Inbred F344 Rats
Intraperitoneal Injections
Sexual Behavior

Keywords

  • 5-HT receptors
  • Female rats
  • Intracranial infusion
  • Intraperitoneal treatment
  • Lordosis
  • Serotonin
  • Ventromedial hypothalamus

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Tropisetron increases the inhibitory effect of mild restraint on lordosis behavior of hormonally primed, ovariectomized rats. / Uphouse, Lynda; Heckard, Danyeal; Hiegel, Cindy; Guptarak, Jutatip; Maswood, Sharmin.

In: Behavioural Brain Research, Vol. 219, No. 2, 01.06.2011, p. 221-226.

Research output: Contribution to journalArticle

Uphouse, Lynda ; Heckard, Danyeal ; Hiegel, Cindy ; Guptarak, Jutatip ; Maswood, Sharmin. / Tropisetron increases the inhibitory effect of mild restraint on lordosis behavior of hormonally primed, ovariectomized rats. In: Behavioural Brain Research. 2011 ; Vol. 219, No. 2. pp. 221-226.
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