Trypanosoma cruzi and Chagas Disease: Innate Immunity, ROS, and Cardiovascular System

Herbert B. Tanowitz, Jian jun Wen, Fabiana S. Machado, Mahalia S. Desruisseaux, Carlos Robello, Nisha J. Garg

Research output: Chapter in Book/Report/Conference proceedingChapter

11 Scopus citations


Chagas disease, caused by Trypanosoma cruzi, remains an important neglected disease and a cause of significant morbidity and mortality. No longer confined to endemic areas of Latin America, it is now found in nonendemic areas due to immigration and/or natural transmission. The pathogenesis of Chagas disease is complex and multifactorial. The significance of innate immunity, including the contributions of cytokines, chemokines, and reactive oxygen species, has been emphasized. The components of the eicosanoid pathway, such as thromboxane A2 and the lipoxins, have profound effects as pro- and anti-inflammatory factors. Additionally, we discuss the vasoconstrictive actions of thromboxane A2 and endothelin-1 in Chagas disease.

Original languageEnglish (US)
Title of host publicationVascular Responses to Pathogens
PublisherElsevier Inc.
Number of pages11
ISBN (Electronic)9780128013250
ISBN (Print)9780128010785
StatePublished - 2016


  • Chagas disease
  • Endothelin
  • Reactive oxygen species
  • Thromboxane A
  • Trypanosoma cruzi
  • Vasoconstriction

ASJC Scopus subject areas

  • General Medicine


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