Trypanosoma cruzi and Chagas Disease

Innate Immunity, ROS, and Cardiovascular System

Herbert B. Tanowitz, Jian jun Wen, Fabiana S. Machado, Mahalia S. Desruisseaux, Carlos Robello, Nisha Garg

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Abstract

Chagas disease, caused by Trypanosoma cruzi, remains an important neglected disease and a cause of significant morbidity and mortality. No longer confined to endemic areas of Latin America, it is now found in nonendemic areas due to immigration and/or natural transmission. The pathogenesis of Chagas disease is complex and multifactorial. The significance of innate immunity, including the contributions of cytokines, chemokines, and reactive oxygen species, has been emphasized. The components of the eicosanoid pathway, such as thromboxane A2 and the lipoxins, have profound effects as pro- and anti-inflammatory factors. Additionally, we discuss the vasoconstrictive actions of thromboxane A2 and endothelin-1 in Chagas disease.

Original languageEnglish (US)
Title of host publicationVascular Responses to Pathogens
PublisherElsevier Inc.
Pages183-193
Number of pages11
ISBN (Electronic)9780128013250
ISBN (Print)9780128010785
DOIs
StatePublished - Oct 27 2015

Fingerprint

Chagas Disease
Trypanosoma cruzi
Cardiovascular System
Innate Immunity
Thromboxane A2
Lipoxins
Neglected Diseases
Eicosanoids
Latin America
Emigration and Immigration
Endothelin-1
Chemokines
Reactive Oxygen Species
Anti-Inflammatory Agents
Cytokines
Morbidity
Mortality

Keywords

  • Chagas disease
  • Endothelin
  • Reactive oxygen species
  • Thromboxane A
  • Trypanosoma cruzi
  • Vasoconstriction

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Tanowitz, H. B., Wen, J. J., Machado, F. S., Desruisseaux, M. S., Robello, C., & Garg, N. (2015). Trypanosoma cruzi and Chagas Disease: Innate Immunity, ROS, and Cardiovascular System. In Vascular Responses to Pathogens (pp. 183-193). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-801078-5.00014-5

Trypanosoma cruzi and Chagas Disease : Innate Immunity, ROS, and Cardiovascular System. / Tanowitz, Herbert B.; Wen, Jian jun; Machado, Fabiana S.; Desruisseaux, Mahalia S.; Robello, Carlos; Garg, Nisha.

Vascular Responses to Pathogens. Elsevier Inc., 2015. p. 183-193.

Research output: Chapter in Book/Report/Conference proceedingChapter

Tanowitz, HB, Wen, JJ, Machado, FS, Desruisseaux, MS, Robello, C & Garg, N 2015, Trypanosoma cruzi and Chagas Disease: Innate Immunity, ROS, and Cardiovascular System. in Vascular Responses to Pathogens. Elsevier Inc., pp. 183-193. https://doi.org/10.1016/B978-0-12-801078-5.00014-5
Tanowitz HB, Wen JJ, Machado FS, Desruisseaux MS, Robello C, Garg N. Trypanosoma cruzi and Chagas Disease: Innate Immunity, ROS, and Cardiovascular System. In Vascular Responses to Pathogens. Elsevier Inc. 2015. p. 183-193 https://doi.org/10.1016/B978-0-12-801078-5.00014-5
Tanowitz, Herbert B. ; Wen, Jian jun ; Machado, Fabiana S. ; Desruisseaux, Mahalia S. ; Robello, Carlos ; Garg, Nisha. / Trypanosoma cruzi and Chagas Disease : Innate Immunity, ROS, and Cardiovascular System. Vascular Responses to Pathogens. Elsevier Inc., 2015. pp. 183-193
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