Trypanosoma cruzi circulating in the southern region of the State of Mexico (Zumpahuacan) are pathogenic: A dog model

Alberto Barbabosa-Pliego, Hector M. Díaz-Albiter, Laucel Ochoa-García, Esteban Aparicio-Burgos, Sandra M. López-Heydeck, Valente Velásquez-Ordoñez, Raul C. Fajardo-Muñoz, Sandra Díaz-González, Roberto Montes De Oca-Jimenez, Marco Barbosa-Mireles, Carmen Guzmán-Bracho, Jose G. Estrada-Franco, Nisha Garg, Juan C. Vázquez-Chagoyán

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Here we describe clinical and pathologic evidence of Chagas disease caused in dogs by circulating Trypanosoma cruzi from a newly recognized endemic area in Mexico. We show that the Zumpahuacan isolate, although less virulent than the Sylvio-X10 reference strain that caused acute myocarditis and death, was pathogenic in dogs. Dogs infected with the Zumpahuacan isolate exhibited electrocardiographic alterations, left- and right-ventricle dilation, and hydropericardium. Histologically, diffused perimysial and endomysial lymphoplasmacytic cell infiltration, cardiomyocyte necrosis, and amastigote nests were noted in Zumpahuacan-infected dogs. These findings suggest that the risk of T. cruzi infection and Chagas disease is present in the State of Mexico, and further research is needed to identify the T. cruzi biotypes circulating in southern State of Mexico.

Original languageEnglish (US)
Pages (from-to)390-395
Number of pages6
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume81
Issue number3
StatePublished - Sep 2009

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Trypanosoma cruzi
Mexico
Dogs
Chagas Disease
Heart Ventricles
Myocarditis
Cardiac Myocytes
Dilatation
Necrosis
Infection
Research

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Virology

Cite this

Barbabosa-Pliego, A., Díaz-Albiter, H. M., Ochoa-García, L., Aparicio-Burgos, E., López-Heydeck, S. M., Velásquez-Ordoñez, V., ... Vázquez-Chagoyán, J. C. (2009). Trypanosoma cruzi circulating in the southern region of the State of Mexico (Zumpahuacan) are pathogenic: A dog model. American Journal of Tropical Medicine and Hygiene, 81(3), 390-395.

Trypanosoma cruzi circulating in the southern region of the State of Mexico (Zumpahuacan) are pathogenic : A dog model. / Barbabosa-Pliego, Alberto; Díaz-Albiter, Hector M.; Ochoa-García, Laucel; Aparicio-Burgos, Esteban; López-Heydeck, Sandra M.; Velásquez-Ordoñez, Valente; Fajardo-Muñoz, Raul C.; Díaz-González, Sandra; De Oca-Jimenez, Roberto Montes; Barbosa-Mireles, Marco; Guzmán-Bracho, Carmen; Estrada-Franco, Jose G.; Garg, Nisha; Vázquez-Chagoyán, Juan C.

In: American Journal of Tropical Medicine and Hygiene, Vol. 81, No. 3, 09.2009, p. 390-395.

Research output: Contribution to journalArticle

Barbabosa-Pliego, A, Díaz-Albiter, HM, Ochoa-García, L, Aparicio-Burgos, E, López-Heydeck, SM, Velásquez-Ordoñez, V, Fajardo-Muñoz, RC, Díaz-González, S, De Oca-Jimenez, RM, Barbosa-Mireles, M, Guzmán-Bracho, C, Estrada-Franco, JG, Garg, N & Vázquez-Chagoyán, JC 2009, 'Trypanosoma cruzi circulating in the southern region of the State of Mexico (Zumpahuacan) are pathogenic: A dog model', American Journal of Tropical Medicine and Hygiene, vol. 81, no. 3, pp. 390-395.
Barbabosa-Pliego A, Díaz-Albiter HM, Ochoa-García L, Aparicio-Burgos E, López-Heydeck SM, Velásquez-Ordoñez V et al. Trypanosoma cruzi circulating in the southern region of the State of Mexico (Zumpahuacan) are pathogenic: A dog model. American Journal of Tropical Medicine and Hygiene. 2009 Sep;81(3):390-395.
Barbabosa-Pliego, Alberto ; Díaz-Albiter, Hector M. ; Ochoa-García, Laucel ; Aparicio-Burgos, Esteban ; López-Heydeck, Sandra M. ; Velásquez-Ordoñez, Valente ; Fajardo-Muñoz, Raul C. ; Díaz-González, Sandra ; De Oca-Jimenez, Roberto Montes ; Barbosa-Mireles, Marco ; Guzmán-Bracho, Carmen ; Estrada-Franco, Jose G. ; Garg, Nisha ; Vázquez-Chagoyán, Juan C. / Trypanosoma cruzi circulating in the southern region of the State of Mexico (Zumpahuacan) are pathogenic : A dog model. In: American Journal of Tropical Medicine and Hygiene. 2009 ; Vol. 81, No. 3. pp. 390-395.
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