TY - JOUR
T1 - Trypanosoma cruzi circulating in the southern region of the State of Mexico (Zumpahuacan) are pathogenic
T2 - A dog model
AU - Barbabosa-Pliego, Alberto
AU - Díaz-Albiter, Hector M.
AU - Ochoa-García, Laucel
AU - Aparicio-Burgos, Esteban
AU - López-Heydeck, Sandra M.
AU - Velásquez-Ordoñez, Valente
AU - Fajardo-Muñoz, Raul C.
AU - Díaz-González, Sandra
AU - De Oca-Jimenez, Roberto Montes
AU - Barbosa-Mireles, Marco
AU - Guzmán-Bracho, Carmen
AU - Estrada-Franco, Jose G.
AU - Garg, Nisha Jain
AU - Vázquez-Chagoyán, Juan C.
PY - 2009/9
Y1 - 2009/9
N2 - Here we describe clinical and pathologic evidence of Chagas disease caused in dogs by circulating Trypanosoma cruzi from a newly recognized endemic area in Mexico. We show that the Zumpahuacan isolate, although less virulent than the Sylvio-X10 reference strain that caused acute myocarditis and death, was pathogenic in dogs. Dogs infected with the Zumpahuacan isolate exhibited electrocardiographic alterations, left- and right-ventricle dilation, and hydropericardium. Histologically, diffused perimysial and endomysial lymphoplasmacytic cell infiltration, cardiomyocyte necrosis, and amastigote nests were noted in Zumpahuacan-infected dogs. These findings suggest that the risk of T. cruzi infection and Chagas disease is present in the State of Mexico, and further research is needed to identify the T. cruzi biotypes circulating in southern State of Mexico.
AB - Here we describe clinical and pathologic evidence of Chagas disease caused in dogs by circulating Trypanosoma cruzi from a newly recognized endemic area in Mexico. We show that the Zumpahuacan isolate, although less virulent than the Sylvio-X10 reference strain that caused acute myocarditis and death, was pathogenic in dogs. Dogs infected with the Zumpahuacan isolate exhibited electrocardiographic alterations, left- and right-ventricle dilation, and hydropericardium. Histologically, diffused perimysial and endomysial lymphoplasmacytic cell infiltration, cardiomyocyte necrosis, and amastigote nests were noted in Zumpahuacan-infected dogs. These findings suggest that the risk of T. cruzi infection and Chagas disease is present in the State of Mexico, and further research is needed to identify the T. cruzi biotypes circulating in southern State of Mexico.
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U2 - 10.4269/ajtmh.2009.81.390
DO - 10.4269/ajtmh.2009.81.390
M3 - Article
C2 - 19706902
AN - SCOPUS:69249187719
VL - 81
SP - 390
EP - 395
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
SN - 0002-9637
IS - 3
ER -