Trypanosoma cruzi circulating in the southern region of the State of Mexico (Zumpahuacan) are pathogenic: A dog model

Alberto Barbabosa-Pliego, Hector M. Díaz-Albiter, Laucel Ochoa-García, Esteban Aparicio-Burgos, Sandra M. López-Heydeck, Valente Velásquez-Ordoñez, Raul C. Fajardo-Muñoz, Sandra Díaz-González, Roberto Montes De Oca-Jimenez, Marco Barbosa-Mireles, Carmen Guzmán-Bracho, Jose G. Estrada-Franco, Nisha Jain Garg, Juan C. Vázquez-Chagoyán

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Here we describe clinical and pathologic evidence of Chagas disease caused in dogs by circulating Trypanosoma cruzi from a newly recognized endemic area in Mexico. We show that the Zumpahuacan isolate, although less virulent than the Sylvio-X10 reference strain that caused acute myocarditis and death, was pathogenic in dogs. Dogs infected with the Zumpahuacan isolate exhibited electrocardiographic alterations, left- and right-ventricle dilation, and hydropericardium. Histologically, diffused perimysial and endomysial lymphoplasmacytic cell infiltration, cardiomyocyte necrosis, and amastigote nests were noted in Zumpahuacan-infected dogs. These findings suggest that the risk of T. cruzi infection and Chagas disease is present in the State of Mexico, and further research is needed to identify the T. cruzi biotypes circulating in southern State of Mexico.

Original languageEnglish (US)
Pages (from-to)390-395
Number of pages6
JournalAmerican Journal of Tropical Medicine and Hygiene
Issue number3
StatePublished - Sep 2009

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology
  • Parasitology


Dive into the research topics of 'Trypanosoma cruzi circulating in the southern region of the State of Mexico (Zumpahuacan) are pathogenic: A dog model'. Together they form a unique fingerprint.

Cite this