Tuftsin and tuftsin analogs: Biology, synthesis and design theory

Kenji Nishioka, John McMurray, Fahad Al Obeidi, B. Montgomery Pettitt

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

We have reviewed aspects of the medicinal chemistry of Tuftsin. Biochemical and clinical aspects including physiology and assays are briefly accounted for. Structure-activity relationships found in the literature provide a link between the synthetic/design strategies and the biological response. Directed rational design and synthetic techniques are reviewed for both tuftsin and its analogs.

Original languageEnglish (US)
Pages (from-to)153-166
Number of pages14
JournalCurrent Medicinal Chemistry
Volume3
Issue number3
StatePublished - Jan 1 1996
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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