Tumor induction in BALB/c female mice after fission neutron or γ irradiation

R. L. Ullrich

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

This study was designed to examine the dose-response relationships for tumor induction after neutron irradiation in female BALB/c mice, with emphasis on the response in the dose range 0 to 50 rad. Tumors induced after radiation exposure included ovarian tumors, lung adenocarcinomas, and mammary adenocarcinomas. For comparison the dose responses for induction of these tumors after 137Cs γ irradiation were also examined. As previously described for the female RFM mouse, the data for ovarian tumor induction after neutron and γ irradiation were consistent with a threshold model. For lung and mammary tumors the dose-response curve after neutron irradiation appeared to 'bend over' in the dose range 10 to 20 rad. The factors responsible for this bend-over and their relative contributions to the overall form of the dose-response relationship are not presently known. However, these data strongly indicate that extrapolation from data above 50 rad could result in a significant underestimate of risks. Further, it is clear that current models of neutron carcinogenesis are inadequate, since such a bend-over is not predicted at these low dose levels.

Original languageEnglish (US)
Pages (from-to)506-515
Number of pages10
JournalRadiation Research
Volume93
Issue number3
StatePublished - 1983
Externally publishedYes

Fingerprint

Neutrons
dose response
fission
mice
induction
tumors
irradiation
neutrons
dosage
neoplasms
ovarian neoplasms
Neoplasms
adenocarcinoma
neutron irradiation
lungs
overdose
mammary neoplasms (animal)
lung neoplasms
carcinogenesis
breasts

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Tumor induction in BALB/c female mice after fission neutron or γ irradiation. / Ullrich, R. L.

In: Radiation Research, Vol. 93, No. 3, 1983, p. 506-515.

Research output: Contribution to journalArticle

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