Tumor induction in BALB/c mice after fractionated or protracted exposures to fission-spectrum neutrons

R. L. Ullrich

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

This study has examined the effect of dose rate or fractionation on the carcinogenic effects of fission neutrons with emphasis on the dose range below 50 rad. The induction of lung adenocarcinomas, mammary adenocarcinomas, and ovarian tumors in female BALB/c mice was examined after whole-body neutron irradiation delivered at a high dose rate as a single exposure, or delivered as two equal fractions separated by intervals of 24 hr or 30 days and compared these effects to those after neutron irradiation at low dose rates. The dose responses for ovarian tumorigenesis after the split-dose fractionation regimen were similar to that observed after single high-dose-rate neutron exposure. However lowering the dose rate reduced the incidence over the dose range of 0-50 rad. For lung and mammary tumors the results were more complex. These data suggest that fractionation and dose-rate effects are different for different tumor types presumably because of the different mechanisms of tumorigenesis that may be involved.

Original languageEnglish (US)
Pages (from-to)587-597
Number of pages11
JournalRadiation Research
Volume97
Issue number3
StatePublished - 1984
Externally publishedYes

Fingerprint

neutron spectra
Neutrons
fission
mice
induction
tumors
Dose Fractionation
dosage
neoplasms
Neoplasms
Carcinogenesis
fractionation
Whole-Body Irradiation
adenocarcinoma
carcinogenesis
neutron irradiation
Adenocarcinoma
Breast
irradiation
lungs

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Tumor induction in BALB/c mice after fractionated or protracted exposures to fission-spectrum neutrons. / Ullrich, R. L.

In: Radiation Research, Vol. 97, No. 3, 1984, p. 587-597.

Research output: Contribution to journalArticle

@article{0e049de0f03740e59e2f613a9760f76e,
title = "Tumor induction in BALB/c mice after fractionated or protracted exposures to fission-spectrum neutrons",
abstract = "This study has examined the effect of dose rate or fractionation on the carcinogenic effects of fission neutrons with emphasis on the dose range below 50 rad. The induction of lung adenocarcinomas, mammary adenocarcinomas, and ovarian tumors in female BALB/c mice was examined after whole-body neutron irradiation delivered at a high dose rate as a single exposure, or delivered as two equal fractions separated by intervals of 24 hr or 30 days and compared these effects to those after neutron irradiation at low dose rates. The dose responses for ovarian tumorigenesis after the split-dose fractionation regimen were similar to that observed after single high-dose-rate neutron exposure. However lowering the dose rate reduced the incidence over the dose range of 0-50 rad. For lung and mammary tumors the results were more complex. These data suggest that fractionation and dose-rate effects are different for different tumor types presumably because of the different mechanisms of tumorigenesis that may be involved.",
author = "Ullrich, {R. L.}",
year = "1984",
language = "English (US)",
volume = "97",
pages = "587--597",
journal = "Radiation Research",
issn = "0033-7587",
publisher = "Radiation Research Society",
number = "3",

}

TY - JOUR

T1 - Tumor induction in BALB/c mice after fractionated or protracted exposures to fission-spectrum neutrons

AU - Ullrich, R. L.

PY - 1984

Y1 - 1984

N2 - This study has examined the effect of dose rate or fractionation on the carcinogenic effects of fission neutrons with emphasis on the dose range below 50 rad. The induction of lung adenocarcinomas, mammary adenocarcinomas, and ovarian tumors in female BALB/c mice was examined after whole-body neutron irradiation delivered at a high dose rate as a single exposure, or delivered as two equal fractions separated by intervals of 24 hr or 30 days and compared these effects to those after neutron irradiation at low dose rates. The dose responses for ovarian tumorigenesis after the split-dose fractionation regimen were similar to that observed after single high-dose-rate neutron exposure. However lowering the dose rate reduced the incidence over the dose range of 0-50 rad. For lung and mammary tumors the results were more complex. These data suggest that fractionation and dose-rate effects are different for different tumor types presumably because of the different mechanisms of tumorigenesis that may be involved.

AB - This study has examined the effect of dose rate or fractionation on the carcinogenic effects of fission neutrons with emphasis on the dose range below 50 rad. The induction of lung adenocarcinomas, mammary adenocarcinomas, and ovarian tumors in female BALB/c mice was examined after whole-body neutron irradiation delivered at a high dose rate as a single exposure, or delivered as two equal fractions separated by intervals of 24 hr or 30 days and compared these effects to those after neutron irradiation at low dose rates. The dose responses for ovarian tumorigenesis after the split-dose fractionation regimen were similar to that observed after single high-dose-rate neutron exposure. However lowering the dose rate reduced the incidence over the dose range of 0-50 rad. For lung and mammary tumors the results were more complex. These data suggest that fractionation and dose-rate effects are different for different tumor types presumably because of the different mechanisms of tumorigenesis that may be involved.

UR - http://www.scopus.com/inward/record.url?scp=0021212968&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021212968&partnerID=8YFLogxK

M3 - Article

VL - 97

SP - 587

EP - 597

JO - Radiation Research

JF - Radiation Research

SN - 0033-7587

IS - 3

ER -