Tumor necrosis factor and the pathogenesis of pichinde virus infection in guinea pigs

J. F. Aronson, N. K. Herzog, T. R. Jerrells

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Pichinde virus (PIC) is a reticuloendothelial arenavirus of the New World tropics. A guinea pig passage-adapted strain of this virus (adPIC) is uniformly lethal for inbred guinea pigs, while the related, prototype strain (PIC3739) has attenuated virulence. The abilities of adPIC and PIC3739 to induce tumor necrosis factor (TNF) in vivo and in cultured macrophages were compared. Infection with adPIC, but not PIC3739, was associated with detectable serum TNF that peaked in week 2 of infection. Tumor necrosis factor was found in the spleens of adPIC-and PIC3739-infected animals in week 1 of infection; TNFα mRNA levels in spleens and livers of adPIC infected animals increased and remained high throughout infection, whereas PIC3739- infected organs showed down regulation of TNFα mRNA late in infection. Peritoneal macrophages explanted from adPIC-infected animals showed enhanced lipopolysaccharide-inducible TNF production. Altered regulation of TNF production may play a role in the pathogenesis of guinea pig arenavirus disease.

Original languageEnglish (US)
Pages (from-to)262-269
Number of pages8
JournalAmerican Journal of Tropical Medicine and Hygiene
Issue number3
StatePublished - 1995

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Virology


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