Tumor remnants within giant cells following irradiation of cutaneous squamous cell carcinoma

Todd Moore, Angela Yen Moore, Mark Langer, Richard Wagner

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

BACKGROUND. The histopathologic effects of curative doses of radiation therapy on cutaneous squamous cell carcinoma (SCC) have not been well described in the dermatologic literature. OBJECTIVE. To understand the histopathologic process of cutaneous SCC involution following radiation treatment. METHODS. Hematoxylin-eosin stain and immunoperoxidase stains for keratin were performed on tissue from the site of a primary cutaneous SCC 2 months after completion of fractionated radiation therapy (7000 cGy total) but prior to clinical involution. RESULTS. Histopathological examination of the irradiated SCC revealed dermal keratin pearls and keratinocytic necrosis resembling apoptosis as well as inflammation and foreign body giant cell reaction. Immunoperoxidase staining for keratin revealed cellular remnants of cutaneous SCC without intact keratinocytic nuclei within giant cells. CONCLUSION. Complete clinical resolution of the SCC over the next several weeks without recurrence after 15 months confirmed the histopathologic findings of tumor destruction by primary radiation therapy.

Original languageEnglish (US)
Pages (from-to)1094-1096
Number of pages3
JournalDermatologic Surgery
Volume24
Issue number10
StatePublished - Oct 1998

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Giant Cells
Squamous Cell Carcinoma
Skin
Keratins
Neoplasms
Radiotherapy
Coloring Agents
Foreign Body Giant Cells
Hematoxylin
Eosine Yellowish-(YS)
Necrosis
Radiation
Apoptosis
Staining and Labeling
Inflammation
Recurrence

ASJC Scopus subject areas

  • Dermatology
  • Surgery

Cite this

Tumor remnants within giant cells following irradiation of cutaneous squamous cell carcinoma. / Moore, Todd; Moore, Angela Yen; Langer, Mark; Wagner, Richard.

In: Dermatologic Surgery, Vol. 24, No. 10, 10.1998, p. 1094-1096.

Research output: Contribution to journalArticle

Moore, Todd ; Moore, Angela Yen ; Langer, Mark ; Wagner, Richard. / Tumor remnants within giant cells following irradiation of cutaneous squamous cell carcinoma. In: Dermatologic Surgery. 1998 ; Vol. 24, No. 10. pp. 1094-1096.
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