Tunneling nanotubes and gap junctions–their role in long-range intercellular communication during development, health, and disease conditions

Jennifer Ariazi, Andrew Benowitz, Vern De Biasi, Monique L. Den Boer, Stephanie Cherqui, Haifeng Cui, Nathalie Douillet, Eliseo Eugenin, David Favre, Spencer Goodman, Karine Gousset, Dorit Hanein, David I. Israel, Shunsuke Kimura, Robert B. Kirkpatrick, Nastaran Kuhn, Claire Jeong, Emil Lou, Robbie Mailliard, Stephen MaioGeorge Okafo, Matthias Osswald, Jennifer Pasquier, Roel Polak, Gabriele Pradel, Bob de Rooij, Peter Schaeffer, Vytenis A. Skeberdis, Ian F. Smith, Ahmad Tanveer, Niels Volkmann, Zhenhua Wu, Chiara Zurzolo

Research output: Contribution to journalReview article

33 Citations (Scopus)

Abstract

Cell-to-cell communication is essential for the organization, coordination, and development of cellular networks and multi-cellular systems. Intercellular communication is mediated by soluble factors (including growth factors, neurotransmitters, and cytokines/chemokines), gap junctions, exosomes and recently described tunneling nanotubes (TNTs). It is unknown whether a combination of these communication mechanisms such as TNTs and gap junctions may be important, but further research is required. TNTs are long cytoplasmic bridges that enable long-range, directed communication between connected cells. The proposed functions of TNTs are diverse and not well understood but have been shown to include the cell-to-cell transfer of vesicles, organelles, electrical stimuli and small molecules. However, the exact role of TNTs and gap junctions for intercellular communication and their impact on disease is still uncertain and thus, the subject of much debate. The combined data from numerous laboratories indicate that some TNT mediate a long-range gap junctional communication to coordinate metabolism and signaling, in relation to infectious, genetic, metabolic, cancer, and age-related diseases. This review aims to describe the current knowledge, challenges and future perspectives to characterize and explore this new intercellular communication system and to design TNT-based therapeutic strategies.

Original languageEnglish (US)
Article number333
JournalFrontiers in Molecular Neuroscience
Volume10
DOIs
StatePublished - Oct 17 2017
Externally publishedYes

Fingerprint

Nanotubes
Health
Gap Junctions
Exosomes
Chemokines
Cell Communication
Organelles
Neurotransmitter Agents
Intercellular Signaling Peptides and Proteins
Cytokines
Research

Keywords

  • Alzheimer
  • Cancer
  • Gap junctions
  • Inflammation
  • Reactivation

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

Tunneling nanotubes and gap junctions–their role in long-range intercellular communication during development, health, and disease conditions. / Ariazi, Jennifer; Benowitz, Andrew; De Biasi, Vern; Den Boer, Monique L.; Cherqui, Stephanie; Cui, Haifeng; Douillet, Nathalie; Eugenin, Eliseo; Favre, David; Goodman, Spencer; Gousset, Karine; Hanein, Dorit; Israel, David I.; Kimura, Shunsuke; Kirkpatrick, Robert B.; Kuhn, Nastaran; Jeong, Claire; Lou, Emil; Mailliard, Robbie; Maio, Stephen; Okafo, George; Osswald, Matthias; Pasquier, Jennifer; Polak, Roel; Pradel, Gabriele; de Rooij, Bob; Schaeffer, Peter; Skeberdis, Vytenis A.; Smith, Ian F.; Tanveer, Ahmad; Volkmann, Niels; Wu, Zhenhua; Zurzolo, Chiara.

In: Frontiers in Molecular Neuroscience, Vol. 10, 333, 17.10.2017.

Research output: Contribution to journalReview article

Ariazi, J, Benowitz, A, De Biasi, V, Den Boer, ML, Cherqui, S, Cui, H, Douillet, N, Eugenin, E, Favre, D, Goodman, S, Gousset, K, Hanein, D, Israel, DI, Kimura, S, Kirkpatrick, RB, Kuhn, N, Jeong, C, Lou, E, Mailliard, R, Maio, S, Okafo, G, Osswald, M, Pasquier, J, Polak, R, Pradel, G, de Rooij, B, Schaeffer, P, Skeberdis, VA, Smith, IF, Tanveer, A, Volkmann, N, Wu, Z & Zurzolo, C 2017, 'Tunneling nanotubes and gap junctions–their role in long-range intercellular communication during development, health, and disease conditions', Frontiers in Molecular Neuroscience, vol. 10, 333. https://doi.org/10.3389/fnmol.2017.00333
Ariazi, Jennifer ; Benowitz, Andrew ; De Biasi, Vern ; Den Boer, Monique L. ; Cherqui, Stephanie ; Cui, Haifeng ; Douillet, Nathalie ; Eugenin, Eliseo ; Favre, David ; Goodman, Spencer ; Gousset, Karine ; Hanein, Dorit ; Israel, David I. ; Kimura, Shunsuke ; Kirkpatrick, Robert B. ; Kuhn, Nastaran ; Jeong, Claire ; Lou, Emil ; Mailliard, Robbie ; Maio, Stephen ; Okafo, George ; Osswald, Matthias ; Pasquier, Jennifer ; Polak, Roel ; Pradel, Gabriele ; de Rooij, Bob ; Schaeffer, Peter ; Skeberdis, Vytenis A. ; Smith, Ian F. ; Tanveer, Ahmad ; Volkmann, Niels ; Wu, Zhenhua ; Zurzolo, Chiara. / Tunneling nanotubes and gap junctions–their role in long-range intercellular communication during development, health, and disease conditions. In: Frontiers in Molecular Neuroscience. 2017 ; Vol. 10.
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AU - Cherqui, Stephanie

AU - Cui, Haifeng

AU - Douillet, Nathalie

AU - Eugenin, Eliseo

AU - Favre, David

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AU - Gousset, Karine

AU - Hanein, Dorit

AU - Israel, David I.

AU - Kimura, Shunsuke

AU - Kirkpatrick, Robert B.

AU - Kuhn, Nastaran

AU - Jeong, Claire

AU - Lou, Emil

AU - Mailliard, Robbie

AU - Maio, Stephen

AU - Okafo, George

AU - Osswald, Matthias

AU - Pasquier, Jennifer

AU - Polak, Roel

AU - Pradel, Gabriele

AU - de Rooij, Bob

AU - Schaeffer, Peter

AU - Skeberdis, Vytenis A.

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