Twenty-four hour integrated concentrations of progesterone, 17-hydroxyprogesterone and cortisol in normal male subjects

James P. Gutai, Walter J. Meyer, A. Avinoam Kowarski, Claude J. Migeon

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

The 24 h integrated concentrations of progesterone, 17-hydroxyprogesterone (17-OHP) and cortisol were determined in 5 male subjects ranging in age from 25 to 36 years. Using a nonthrombogenic catheter and a constant withdrawal pump, blood was collected for a period of 24 h in 30 min aliquots. All five subjects had similar 24 h integrated concentrations of cortisol (9.2 ± 5.4). One subject had elevated 24 h integrated concentrations of progesterone (55.2 ± 18.7) and 17-OHP (352 ± 122) when compared to the mean integrated concentrations (progesterone: 24.9 ± 4.7; 17-OHP: 109 ± 33) of the 4 other subjects. The 30 min integrated concentrations showed a diurnal variation for both 17-OHP and cortisol but not for progesterone. The best correlation between cortisol and 17-OHP occurred when the concentrations of cortisol were correlated with the concentrations of 17-OHP 90 or 120 min earlier. No significant correlation occurred between cortisol and progesterone.

Original languageEnglish (US)
Pages (from-to)116-120
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume44
Issue number1
DOIs
StatePublished - Jan 1977

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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