Twin preterm neonates with cardiac toxicity related to lopinavir/ritonavir therapy

Monica A. McArthur; Stella U. Kalu; Arlen R. Foulks; Ashraf M. Aly; Sunil K. Jain; Janak A. Patel

doi:10.1097/INF.0b013e3181acd17e

Twin preterm neonates with cardiac toxicity related to lopinavir/ritonavir therapy

Monica A. McArthur, Stella U. Kalu, Arlen R. Foulks, Ashraf M. Aly, Sunil K. Jain, Janak A. Patel

Pediatrics

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

We report twin neonates who were born prematurely at 32 weeks of gestation to a mother with human immunodeficiency virus infection. One of the twins developed complete heart block and dilated cardiomyopathy related to lopinavir/ritonavir therapy, a boosted protease-inhibitor agent, while the other twin developed mild bradycardia. We recommend caution in the use of lopinavir/ritonavir in the immediate neonatal period.

Original language	English (US)
Pages (from-to)	1127-1129
Number of pages	3
Journal	Pediatric Infectious Disease Journal
Volume	28
Issue number	12
DOIs	https://doi.org/10.1097/INF.0b013e3181acd17e
State	Published - Dec 2009

Keywords

Antiretroviral therapy
Heart block
Lopinavir/ritonavir

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Microbiology (medical)
Infectious Diseases

Access to Document

10.1097/INF.0b013e3181acd17e

Cite this

@article{5de467f301ff4cad949065af305b70f4,

title = "Twin preterm neonates with cardiac toxicity related to lopinavir/ritonavir therapy",

abstract = "We report twin neonates who were born prematurely at 32 weeks of gestation to a mother with human immunodeficiency virus infection. One of the twins developed complete heart block and dilated cardiomyopathy related to lopinavir/ritonavir therapy, a boosted protease-inhibitor agent, while the other twin developed mild bradycardia. We recommend caution in the use of lopinavir/ritonavir in the immediate neonatal period.",

keywords = "Antiretroviral therapy, Heart block, Lopinavir/ritonavir",

author = "McArthur, {Monica A.} and Kalu, {Stella U.} and Foulks, {Arlen R.} and Aly, {Ashraf M.} and Jain, {Sunil K.} and Patel, {Janak A.}",

year = "2009",

month = dec,

doi = "10.1097/INF.0b013e3181acd17e",

language = "English (US)",

volume = "28",

pages = "1127--1129",

journal = "Pediatric Infectious Disease Journal",

issn = "0891-3668",

publisher = "Lippincott Williams and Wilkins",

number = "12",

}

TY - JOUR

T1 - Twin preterm neonates with cardiac toxicity related to lopinavir/ritonavir therapy

AU - McArthur, Monica A.

AU - Kalu, Stella U.

AU - Foulks, Arlen R.

AU - Aly, Ashraf M.

AU - Jain, Sunil K.

AU - Patel, Janak A.

PY - 2009/12

Y1 - 2009/12

N2 - We report twin neonates who were born prematurely at 32 weeks of gestation to a mother with human immunodeficiency virus infection. One of the twins developed complete heart block and dilated cardiomyopathy related to lopinavir/ritonavir therapy, a boosted protease-inhibitor agent, while the other twin developed mild bradycardia. We recommend caution in the use of lopinavir/ritonavir in the immediate neonatal period.

AB - We report twin neonates who were born prematurely at 32 weeks of gestation to a mother with human immunodeficiency virus infection. One of the twins developed complete heart block and dilated cardiomyopathy related to lopinavir/ritonavir therapy, a boosted protease-inhibitor agent, while the other twin developed mild bradycardia. We recommend caution in the use of lopinavir/ritonavir in the immediate neonatal period.

KW - Antiretroviral therapy

KW - Heart block

KW - Lopinavir/ritonavir

UR - http://www.scopus.com/inward/record.url?scp=74049102915&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=74049102915&partnerID=8YFLogxK

U2 - 10.1097/INF.0b013e3181acd17e

DO - 10.1097/INF.0b013e3181acd17e

M3 - Article

C2 - 19820426

AN - SCOPUS:74049102915

SN - 0891-3668

VL - 28

SP - 1127

EP - 1129

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

IS - 12

ER -

Twin preterm neonates with cardiac toxicity related to lopinavir/ritonavir therapy

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this