Twin preterm neonates with cardiac toxicity related to lopinavir/ritonavir therapy

Monica A. McArthur, Stella U. Kalu, Arlen R. Foulks, Ashraf Aly, Sunil Jain, Janak Patel

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We report twin neonates who were born prematurely at 32 weeks of gestation to a mother with human immunodeficiency virus infection. One of the twins developed complete heart block and dilated cardiomyopathy related to lopinavir/ritonavir therapy, a boosted protease-inhibitor agent, while the other twin developed mild bradycardia. We recommend caution in the use of lopinavir/ritonavir in the immediate neonatal period.

Original languageEnglish (US)
Pages (from-to)1127-1129
Number of pages3
JournalPediatric Infectious Disease Journal
Volume28
Issue number12
DOIs
StatePublished - Dec 2009

Fingerprint

Lopinavir
Ritonavir
Heart Block
Dilated Cardiomyopathy
Virus Diseases
Bradycardia
Protease Inhibitors
HIV
Pregnancy
Therapeutics
Cardiotoxicity

Keywords

  • Antiretroviral therapy
  • Heart block
  • Lopinavir/ritonavir

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases
  • Microbiology (medical)

Cite this

Twin preterm neonates with cardiac toxicity related to lopinavir/ritonavir therapy. / McArthur, Monica A.; Kalu, Stella U.; Foulks, Arlen R.; Aly, Ashraf; Jain, Sunil; Patel, Janak.

In: Pediatric Infectious Disease Journal, Vol. 28, No. 12, 12.2009, p. 1127-1129.

Research output: Contribution to journalArticle

McArthur, Monica A. ; Kalu, Stella U. ; Foulks, Arlen R. ; Aly, Ashraf ; Jain, Sunil ; Patel, Janak. / Twin preterm neonates with cardiac toxicity related to lopinavir/ritonavir therapy. In: Pediatric Infectious Disease Journal. 2009 ; Vol. 28, No. 12. pp. 1127-1129.
@article{5de467f301ff4cad949065af305b70f4,
title = "Twin preterm neonates with cardiac toxicity related to lopinavir/ritonavir therapy",
abstract = "We report twin neonates who were born prematurely at 32 weeks of gestation to a mother with human immunodeficiency virus infection. One of the twins developed complete heart block and dilated cardiomyopathy related to lopinavir/ritonavir therapy, a boosted protease-inhibitor agent, while the other twin developed mild bradycardia. We recommend caution in the use of lopinavir/ritonavir in the immediate neonatal period.",
keywords = "Antiretroviral therapy, Heart block, Lopinavir/ritonavir",
author = "McArthur, {Monica A.} and Kalu, {Stella U.} and Foulks, {Arlen R.} and Ashraf Aly and Sunil Jain and Janak Patel",
year = "2009",
month = "12",
doi = "10.1097/INF.0b013e3181acd17e",
language = "English (US)",
volume = "28",
pages = "1127--1129",
journal = "Pediatric Infectious Disease Journal",
issn = "0891-3668",
publisher = "Lippincott Williams and Wilkins",
number = "12",

}

TY - JOUR

T1 - Twin preterm neonates with cardiac toxicity related to lopinavir/ritonavir therapy

AU - McArthur, Monica A.

AU - Kalu, Stella U.

AU - Foulks, Arlen R.

AU - Aly, Ashraf

AU - Jain, Sunil

AU - Patel, Janak

PY - 2009/12

Y1 - 2009/12

N2 - We report twin neonates who were born prematurely at 32 weeks of gestation to a mother with human immunodeficiency virus infection. One of the twins developed complete heart block and dilated cardiomyopathy related to lopinavir/ritonavir therapy, a boosted protease-inhibitor agent, while the other twin developed mild bradycardia. We recommend caution in the use of lopinavir/ritonavir in the immediate neonatal period.

AB - We report twin neonates who were born prematurely at 32 weeks of gestation to a mother with human immunodeficiency virus infection. One of the twins developed complete heart block and dilated cardiomyopathy related to lopinavir/ritonavir therapy, a boosted protease-inhibitor agent, while the other twin developed mild bradycardia. We recommend caution in the use of lopinavir/ritonavir in the immediate neonatal period.

KW - Antiretroviral therapy

KW - Heart block

KW - Lopinavir/ritonavir

UR - http://www.scopus.com/inward/record.url?scp=74049102915&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=74049102915&partnerID=8YFLogxK

U2 - 10.1097/INF.0b013e3181acd17e

DO - 10.1097/INF.0b013e3181acd17e

M3 - Article

VL - 28

SP - 1127

EP - 1129

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

SN - 0891-3668

IS - 12

ER -