Twin preterm neonates with cardiac toxicity related to lopinavir/ritonavir therapy

Monica A. McArthur, Stella U. Kalu, Arlen R. Foulks, Ashraf M. Aly, Sunil K. Jain, Janak A. Patel

Research output: Contribution to journalArticle

18 Scopus citations


We report twin neonates who were born prematurely at 32 weeks of gestation to a mother with human immunodeficiency virus infection. One of the twins developed complete heart block and dilated cardiomyopathy related to lopinavir/ritonavir therapy, a boosted protease-inhibitor agent, while the other twin developed mild bradycardia. We recommend caution in the use of lopinavir/ritonavir in the immediate neonatal period.

Original languageEnglish (US)
Pages (from-to)1127-1129
Number of pages3
JournalPediatric Infectious Disease Journal
Issue number12
StatePublished - Dec 2009



  • Antiretroviral therapy
  • Heart block
  • Lopinavir/ritonavir

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

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