Twin preterm neonates with cardiac toxicity related to lopinavir/ritonavir therapy

Monica A. McArthur; Stella U. Kalu; Arlen R. Foulks; Ashraf M. Aly; Sunil K. Jain; Janak A. Patel

doi:10.1097/INF.0b013e3181acd17e

Twin preterm neonates with cardiac toxicity related to lopinavir/ritonavir therapy

Monica A. McArthur
, Stella U. Kalu
, Arlen R. Foulks
, Ashraf M. Aly
, Sunil K. Jain
, Janak A. Patel

Pediatrics

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

We report twin neonates who were born prematurely at 32 weeks of gestation to a mother with human immunodeficiency virus infection. One of the twins developed complete heart block and dilated cardiomyopathy related to lopinavir/ritonavir therapy, a boosted protease-inhibitor agent, while the other twin developed mild bradycardia. We recommend caution in the use of lopinavir/ritonavir in the immediate neonatal period.

Original language	English (US)
Pages (from-to)	1127-1129
Number of pages	3
Journal	Pediatric Infectious Disease Journal
Volume	28
Issue number	12
DOIs	https://doi.org/10.1097/INF.0b013e3181acd17e
State	Published - Dec 2009

Keywords

Antiretroviral therapy
Heart block
Lopinavir/ritonavir

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Microbiology (medical)
Infectious Diseases

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10.1097/INF.0b013e3181acd17e

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abstract = "We report twin neonates who were born prematurely at 32 weeks of gestation to a mother with human immunodeficiency virus infection. One of the twins developed complete heart block and dilated cardiomyopathy related to lopinavir/ritonavir therapy, a boosted protease-inhibitor agent, while the other twin developed mild bradycardia. We recommend caution in the use of lopinavir/ritonavir in the immediate neonatal period.",

keywords = "Antiretroviral therapy, Heart block, Lopinavir/ritonavir",

author = "McArthur, \{Monica A.\} and Kalu, \{Stella U.\} and Foulks, \{Arlen R.\} and Aly, \{Ashraf M.\} and Jain, \{Sunil K.\} and Patel, \{Janak A.\}",

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AU - McArthur, Monica A.

AU - Kalu, Stella U.

AU - Foulks, Arlen R.

AU - Aly, Ashraf M.

AU - Jain, Sunil K.

AU - Patel, Janak A.

PY - 2009/12

Y1 - 2009/12

N2 - We report twin neonates who were born prematurely at 32 weeks of gestation to a mother with human immunodeficiency virus infection. One of the twins developed complete heart block and dilated cardiomyopathy related to lopinavir/ritonavir therapy, a boosted protease-inhibitor agent, while the other twin developed mild bradycardia. We recommend caution in the use of lopinavir/ritonavir in the immediate neonatal period.

AB - We report twin neonates who were born prematurely at 32 weeks of gestation to a mother with human immunodeficiency virus infection. One of the twins developed complete heart block and dilated cardiomyopathy related to lopinavir/ritonavir therapy, a boosted protease-inhibitor agent, while the other twin developed mild bradycardia. We recommend caution in the use of lopinavir/ritonavir in the immediate neonatal period.

KW - Antiretroviral therapy

KW - Heart block

KW - Lopinavir/ritonavir

UR - https://www.scopus.com/pages/publications/74049102915

UR - https://www.scopus.com/pages/publications/74049102915#tab=citedBy

U2 - 10.1097/INF.0b013e3181acd17e

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JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

IS - 12

ER -

Twin preterm neonates with cardiac toxicity related to lopinavir/ritonavir therapy

Abstract

Keywords

ASJC Scopus subject areas

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