Two cases of Hantavirus pulmonary syndrome in Randolph County, West Virginia

A coincidence of time and place?

Julie R. Sinclair, Darin S. Carroll, Joel M. Montgomery, Boris Pavlin, Katherine McCombs, James N. Mills, James A. Comer, Thomas Ksiazek, Pierre E. Rollin, Stuart T. Nichol, Angela J. Sanchez, Christina L. Hutson, Michael Bell, Jane A. Rooney

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Hantavirus pulmonary syndrome (HPS) is caused by an infection with viruses of the genus Hantavirus in the western hemisphere. Rodent hosts of hantaviruses are present throughout the United States. In July 2004, two HPS case-patients were identified in Randolph County, WV: a wildlife science graduate student working locally and a Randolph County resident. We interviewed family members and colleagues, reviewed medical records, and conducted environmental studies at likely exposure sites. Small mammals were trapped, and blood, urine, and tissue samples were submitted to the Centers for Disease Control and Prevention for laboratory analyses. These analyses confirmed that both patients were infected with Monongahela virus, a Sin Nombre hantavirus variant hosted by the Cloudland deer mouse, Peromyscus maniculatus nubiterrae. Other than one retrospectively diagnosed case in 1981, these are the first HPS cases reported in West Virginia. These cases emphasize the need to educate the public throughout the United States regarding risks and prevention measures for hantavirus infection.

Original languageEnglish (US)
Pages (from-to)438-442
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume76
Issue number3
StatePublished - Mar 2007
Externally publishedYes

Fingerprint

Hantavirus Pulmonary Syndrome
Hantavirus
Peromyscus
Sin Nombre virus
Hantavirus Infections
Virus Diseases
Centers for Disease Control and Prevention (U.S.)
Medical Records
Mammals
Rodentia
Urine
Students

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Sinclair, J. R., Carroll, D. S., Montgomery, J. M., Pavlin, B., McCombs, K., Mills, J. N., ... Rooney, J. A. (2007). Two cases of Hantavirus pulmonary syndrome in Randolph County, West Virginia: A coincidence of time and place? American Journal of Tropical Medicine and Hygiene, 76(3), 438-442.

Two cases of Hantavirus pulmonary syndrome in Randolph County, West Virginia : A coincidence of time and place? / Sinclair, Julie R.; Carroll, Darin S.; Montgomery, Joel M.; Pavlin, Boris; McCombs, Katherine; Mills, James N.; Comer, James A.; Ksiazek, Thomas; Rollin, Pierre E.; Nichol, Stuart T.; Sanchez, Angela J.; Hutson, Christina L.; Bell, Michael; Rooney, Jane A.

In: American Journal of Tropical Medicine and Hygiene, Vol. 76, No. 3, 03.2007, p. 438-442.

Research output: Contribution to journalArticle

Sinclair, JR, Carroll, DS, Montgomery, JM, Pavlin, B, McCombs, K, Mills, JN, Comer, JA, Ksiazek, T, Rollin, PE, Nichol, ST, Sanchez, AJ, Hutson, CL, Bell, M & Rooney, JA 2007, 'Two cases of Hantavirus pulmonary syndrome in Randolph County, West Virginia: A coincidence of time and place?', American Journal of Tropical Medicine and Hygiene, vol. 76, no. 3, pp. 438-442.
Sinclair, Julie R. ; Carroll, Darin S. ; Montgomery, Joel M. ; Pavlin, Boris ; McCombs, Katherine ; Mills, James N. ; Comer, James A. ; Ksiazek, Thomas ; Rollin, Pierre E. ; Nichol, Stuart T. ; Sanchez, Angela J. ; Hutson, Christina L. ; Bell, Michael ; Rooney, Jane A. / Two cases of Hantavirus pulmonary syndrome in Randolph County, West Virginia : A coincidence of time and place?. In: American Journal of Tropical Medicine and Hygiene. 2007 ; Vol. 76, No. 3. pp. 438-442.
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