Two distinct types of intraneuronal neurofibrillary tangles highlighted by polarized light after silver impregnation with a modified Bielschowsky method

Miguel Pappolla, R. Omar, T. J. Theodoropoulos

Research output: Contribution to journalArticle


Neurofibrillary tangles (NFTs) are one of the morphological hallmarks of Alzheimer's disease. The birefringency and dichroism of NFTs following congo red staining have long been known. Herein, we report the observation that a subset of NFTs show distinct birefringency induced by a modified Bielschowsky silver impregnation method. Birefringency of NFTs could not be elicited after silver impregnation with one other version of the Bielschowsky method or with the Bodian technique. To our knowledge, these properties of NFTs after metal impregnation have not been previously documented.

Original languageEnglish (US)
Pages (from-to)131-133
Number of pages3
JournalArchives of Pathology and Laboratory Medicine
Issue number2
StatePublished - 1991
Externally publishedYes


ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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