Abstract
Two new lanostanoid triterpenes named 3β-hydroxy-4,4,14-trimethyl-7, 11,15-trioxochol-8-en-24-oic acid (1) and 3β-hydroxy-7,11,12,15,23- pentaoxo-lanost-8-en-26-oic acid (2) were isolated from the fruit bodies of Ganoderma lucidum, which is the major component of the antitumor product SunRecome®. Their cytotoxic activities were assayed in vitro against HeLa, p388, SGC-7901, BEL-7402 cell lines, and the results showed that 1 had IC 50 values of 18.00 μM against p388 cell, 12.70 μM against Hela cell, 22.00 μM against BEL-7402 cell, 1.50 μM against SGC-7901 cell and 2 had IC50 values of 9.85 μM against p388 cell, 17.10 μM against Hela cell, 51.00 μM against BEL-7402 cell, 42.00 μM against SGC-7901 cell.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 177-181 |
| Number of pages | 5 |
| Journal | Natural Product Communications |
| Volume | 1 |
| Issue number | 3 |
| State | Published - 2006 |
| Externally published | Yes |
Keywords
- Cytotoxic lanostanoid triterpenes
- Ganoderma lucidum
- SunRecome®
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery
- Plant Science
- Complementary and alternative medicine