Two new lanostanoid triterpenes from the fruit body of Ganoderma lucidum-the major component of SunRecome®

Shu Hong Guan, Min Yang, Xuan Liu, Jia Meng Xia, Xiao-Ming Wang, Hui Jin, De An Guo

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Two new lanostanoid triterpenes named 3β-hydroxy-4,4,14-trimethyl-7, 11,15-trioxochol-8-en-24-oic acid (1) and 3β-hydroxy-7,11,12,15,23- pentaoxo-lanost-8-en-26-oic acid (2) were isolated from the fruit bodies of Ganoderma lucidum, which is the major component of the antitumor product SunRecome®. Their cytotoxic activities were assayed in vitro against HeLa, p388, SGC-7901, BEL-7402 cell lines, and the results showed that 1 had IC 50 values of 18.00 μM against p388 cell, 12.70 μM against Hela cell, 22.00 μM against BEL-7402 cell, 1.50 μM against SGC-7901 cell and 2 had IC50 values of 9.85 μM against p388 cell, 17.10 μM against Hela cell, 51.00 μM against BEL-7402 cell, 42.00 μM against SGC-7901 cell.

Original languageEnglish (US)
Pages (from-to)177-181
Number of pages5
JournalNatural Product Communications
Volume1
Issue number3
StatePublished - 2006
Externally publishedYes

Fingerprint

Reishi
Ganoderma lucidum
Triterpenes
fruiting bodies
triterpenoids
Fruit
cells
HeLa Cells
inhibitory concentration 50
Acids
Inhibitory Concentration 50
lanostanoid
acids
Cell Line
cell lines

Keywords

  • Cytotoxic lanostanoid triterpenes
  • Ganoderma lucidum
  • SunRecome®

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Complementary and alternative medicine
  • Plant Science

Cite this

Two new lanostanoid triterpenes from the fruit body of Ganoderma lucidum-the major component of SunRecome®. / Guan, Shu Hong; Yang, Min; Liu, Xuan; Xia, Jia Meng; Wang, Xiao-Ming; Jin, Hui; Guo, De An.

In: Natural Product Communications, Vol. 1, No. 3, 2006, p. 177-181.

Research output: Contribution to journalArticle

Guan, Shu Hong ; Yang, Min ; Liu, Xuan ; Xia, Jia Meng ; Wang, Xiao-Ming ; Jin, Hui ; Guo, De An. / Two new lanostanoid triterpenes from the fruit body of Ganoderma lucidum-the major component of SunRecome®. In: Natural Product Communications. 2006 ; Vol. 1, No. 3. pp. 177-181.
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AU - Guo, De An

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