Two new lanostanoid triterpenes from the fruit body of Ganoderma lucidum-the major component of SunRecome®

Shu Hong Guan, Min Yang, Xuan Liu, Jia Meng Xia, Xiao Ming Wang, Hui Jin, De An Guo

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Two new lanostanoid triterpenes named 3β-hydroxy-4,4,14-trimethyl-7, 11,15-trioxochol-8-en-24-oic acid (1) and 3β-hydroxy-7,11,12,15,23- pentaoxo-lanost-8-en-26-oic acid (2) were isolated from the fruit bodies of Ganoderma lucidum, which is the major component of the antitumor product SunRecome®. Their cytotoxic activities were assayed in vitro against HeLa, p388, SGC-7901, BEL-7402 cell lines, and the results showed that 1 had IC 50 values of 18.00 μM against p388 cell, 12.70 μM against Hela cell, 22.00 μM against BEL-7402 cell, 1.50 μM against SGC-7901 cell and 2 had IC50 values of 9.85 μM against p388 cell, 17.10 μM against Hela cell, 51.00 μM against BEL-7402 cell, 42.00 μM against SGC-7901 cell.

Original languageEnglish (US)
Pages (from-to)177-181
Number of pages5
JournalNatural Product Communications
Volume1
Issue number3
StatePublished - Jan 1 2006
Externally publishedYes

Keywords

  • Cytotoxic lanostanoid triterpenes
  • Ganoderma lucidum
  • SunRecome®

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Plant Science
  • Complementary and alternative medicine

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