TY - JOUR
T1 - Two-Photon Detection of Organotin Schiff Base Complexes in Cancer Cells
AU - Berrones-Reyes, Jessica C.
AU - Muñoz-Flores, Blanca M.
AU - Uscanga-Palomeque, Ashanti Concepción
AU - Santillán, Rosa
AU - Del Angel-Mosqueda, Casiano
AU - Nobis, David
AU - Cochrane, Max A.
AU - Magennis, Steven W.
AU - Jiménez-Pérez, Víctor M.
N1 - Publisher Copyright:
© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2020/2/7
Y1 - 2020/2/7
N2 - The early detection of cancer cells and their visualization before and after surgery are essential for successful pre- and post-operative disease management. Although fluorescence imaging is a sensitive and versatile tool that is finding increasing use in clinical applications, there is a lack of tumour-targeting fluorophores. We report here a family of fluorescent Schiff base organotin dyes (1: Et2N−L-SnPh2, 2: Et2N−L-SnBu2, 3: MeO−L-SnPh2, 4: MeO−L-SnBu2, 5: HO−L-SnPh2, and 6: HO−L-SnBu2, where L=2-hydroxybenzylidene-4-hydroxybenzhydrazine). In addition to one-photon-excited fluorescence, efficient two-photon excitation was demonstrated in compounds 1–4. Two of the compounds (5 and 6), both with hydroxyl substituents, were capable of selective accumulation in HeLa cells, allowing differentiation from normal cells (periodontal ligament cells). Compounds 1 and 3 showed excellent cancer cell staining (HeLa) using two-photon bioimaging, which is promising for biomedicine applications.
AB - The early detection of cancer cells and their visualization before and after surgery are essential for successful pre- and post-operative disease management. Although fluorescence imaging is a sensitive and versatile tool that is finding increasing use in clinical applications, there is a lack of tumour-targeting fluorophores. We report here a family of fluorescent Schiff base organotin dyes (1: Et2N−L-SnPh2, 2: Et2N−L-SnBu2, 3: MeO−L-SnPh2, 4: MeO−L-SnBu2, 5: HO−L-SnPh2, and 6: HO−L-SnBu2, where L=2-hydroxybenzylidene-4-hydroxybenzhydrazine). In addition to one-photon-excited fluorescence, efficient two-photon excitation was demonstrated in compounds 1–4. Two of the compounds (5 and 6), both with hydroxyl substituents, were capable of selective accumulation in HeLa cells, allowing differentiation from normal cells (periodontal ligament cells). Compounds 1 and 3 showed excellent cancer cell staining (HeLa) using two-photon bioimaging, which is promising for biomedicine applications.
KW - Organotin
KW - cancer detection
KW - fluorescent bioimaging
KW - two-photon excitation
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U2 - 10.1002/slct.201904816
DO - 10.1002/slct.201904816
M3 - Article
AN - SCOPUS:85079071260
SN - 2365-6549
VL - 5
SP - 1623
EP - 1627
JO - ChemistrySelect
JF - ChemistrySelect
IS - 5
ER -