Type i interferon responses in rhesus macaques prevent SIV infection and slow disease progression

Netanya G. Sandler, Steven E. Bosinger, Jacob D. Estes, Richard T R Zhu, Gregory K. Tharp, Eli Boritz, Doron Levin, Sathi Wijeyesinghe, Krystelle Nganou Makamdop, Gregory Q. Del Prete, Brenna J. Hill, J. Katherina Timmer, Emma Reiss, Ganit Yarden, Samuel Darko, Eduardo Contijoch, John Paul Todd, Guido Silvestri, Martha Nason, Robert B. NorgrenBrandon F. Keele, Srinivas Rao, Jerome A. Langer, Jeffrey D. Lifson, Gideon Schreiber, Daniel C. Douek

Research output: Contribution to journalArticle

237 Citations (Scopus)

Abstract

Inflammation in HIV infection is predictive of non-AIDS morbidity and death, higher set point plasma virus load2 and virus acquisition; thus, therapeutic agents are in development to reduce its causes and consequences. However, inflammation may simultaneously confer both detrimental and beneficial effects. This dichotomy is particularly applicable to type I interferons (IFN-I) which, while contributing to innate control of infection4-10, also provide target cells for the virus during acute infection, impair CD4 T-cell recovery, and are associated with disease progression6,7,11-19. Here we manipulated IFN-I signalling in rhesus macaques (Macaca mulatta) during simian immunodeficiency virus (SIV) transmission and acute infection with two complementary in vivo interventions. We show that blockade of the IFN-I receptor caused reduced antiviral gene expression, increased SIV reservoir size and accelerated CD4 T-cell depletion with progression to AIDS despite decreased T-cell activation. In contrast, IFN-α2a administration initially upregulated expression of antiviral genes and prevented systemic infection. However, continued IFN-α2a treatment induced IFN-I desensitization and decreased antiviral gene expression, enabling infection with increased SIV reservoir size and accelerated CD4 T-cell loss. Thus, the timing of IFN-induced innate responses in acute SIV infection profoundly affects overall disease course and outweighs the detrimental consequences of increased immune activation. Yet, the clinical consequences of manipulation of IFN signalling are difficult to predict in vivo and therapeutic interventions in human studies should be approached with caution.

Original languageEnglish (US)
Pages (from-to)601-605
Number of pages5
JournalNature
Volume511
Issue number7511
DOIs
StatePublished - 2014

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Simian Immunodeficiency Virus
Virus Diseases
Macaca mulatta
Interferons
Disease Progression
Antiviral Agents
T-Lymphocytes
Viruses
Gene Expression
Infection
Inflammation
Interferon Type I
Infectious Disease Transmission
HIV Infections
Acquired Immunodeficiency Syndrome
Morbidity
Therapeutics

ASJC Scopus subject areas

  • General

Cite this

Sandler, N. G., Bosinger, S. E., Estes, J. D., Zhu, R. T. R., Tharp, G. K., Boritz, E., ... Douek, D. C. (2014). Type i interferon responses in rhesus macaques prevent SIV infection and slow disease progression. Nature, 511(7511), 601-605. https://doi.org/10.1038/nature13554

Type i interferon responses in rhesus macaques prevent SIV infection and slow disease progression. / Sandler, Netanya G.; Bosinger, Steven E.; Estes, Jacob D.; Zhu, Richard T R; Tharp, Gregory K.; Boritz, Eli; Levin, Doron; Wijeyesinghe, Sathi; Makamdop, Krystelle Nganou; Del Prete, Gregory Q.; Hill, Brenna J.; Timmer, J. Katherina; Reiss, Emma; Yarden, Ganit; Darko, Samuel; Contijoch, Eduardo; Todd, John Paul; Silvestri, Guido; Nason, Martha; Norgren, Robert B.; Keele, Brandon F.; Rao, Srinivas; Langer, Jerome A.; Lifson, Jeffrey D.; Schreiber, Gideon; Douek, Daniel C.

In: Nature, Vol. 511, No. 7511, 2014, p. 601-605.

Research output: Contribution to journalArticle

Sandler, NG, Bosinger, SE, Estes, JD, Zhu, RTR, Tharp, GK, Boritz, E, Levin, D, Wijeyesinghe, S, Makamdop, KN, Del Prete, GQ, Hill, BJ, Timmer, JK, Reiss, E, Yarden, G, Darko, S, Contijoch, E, Todd, JP, Silvestri, G, Nason, M, Norgren, RB, Keele, BF, Rao, S, Langer, JA, Lifson, JD, Schreiber, G & Douek, DC 2014, 'Type i interferon responses in rhesus macaques prevent SIV infection and slow disease progression', Nature, vol. 511, no. 7511, pp. 601-605. https://doi.org/10.1038/nature13554
Sandler NG, Bosinger SE, Estes JD, Zhu RTR, Tharp GK, Boritz E et al. Type i interferon responses in rhesus macaques prevent SIV infection and slow disease progression. Nature. 2014;511(7511):601-605. https://doi.org/10.1038/nature13554
Sandler, Netanya G. ; Bosinger, Steven E. ; Estes, Jacob D. ; Zhu, Richard T R ; Tharp, Gregory K. ; Boritz, Eli ; Levin, Doron ; Wijeyesinghe, Sathi ; Makamdop, Krystelle Nganou ; Del Prete, Gregory Q. ; Hill, Brenna J. ; Timmer, J. Katherina ; Reiss, Emma ; Yarden, Ganit ; Darko, Samuel ; Contijoch, Eduardo ; Todd, John Paul ; Silvestri, Guido ; Nason, Martha ; Norgren, Robert B. ; Keele, Brandon F. ; Rao, Srinivas ; Langer, Jerome A. ; Lifson, Jeffrey D. ; Schreiber, Gideon ; Douek, Daniel C. / Type i interferon responses in rhesus macaques prevent SIV infection and slow disease progression. In: Nature. 2014 ; Vol. 511, No. 7511. pp. 601-605.
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AU - Reiss, Emma

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AU - Darko, Samuel

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AU - Todd, John Paul

AU - Silvestri, Guido

AU - Nason, Martha

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AU - Keele, Brandon F.

AU - Rao, Srinivas

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