Type I Interferon: Understanding Its Role in HIV Pathogenesis and Therapy

Steven E. Bosinger, Netanya S. Utay

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Despite over 30 years of research, the contribution of type I interferons (IFN-Is) to both the control of HIV replication and initiation of immunologic damage remains debated. In acute infection, IFN-Is, likely from plasmacytoid dendritic cells (pDCs), activate NK cells and upregulate restriction factors targeting virtually the entire HIV life cycle. In chronic infection, IFN-Is may also contribute to CD4 T cell loss and immune exhaustion. pDCs subsequently infiltrate lymphoid and mucosal tissues, and their circulating populations wane in chronic infection; IFN-I may be produced by other cells. Data from nonhuman primates indicate prompt IFN-I signaling is critical in acute infection. Whereas some studies showed IFN-I administration without combination antiretroviral therapy (cART) is beneficial, others suggest that stimulating or blocking IFN-I signaling in chronic ART-suppressed HIV infection has had positive results. Here, we describe the history of HIV and IFN-I, IFN-I’s sources, IFN-I’s effects on HIV control and host defense, and recent interventional studies in SIV and HIV infection.

Original languageEnglish (US)
Pages (from-to)41-53
Number of pages13
JournalCurrent HIV/AIDS Reports
Volume12
Issue number1
DOIs
StatePublished - 2015

Fingerprint

Interferon Type I
HIV
Infection
Dendritic Cells
HIV Infections
Lymphoid Tissue
Therapeutics
Life Cycle Stages
Natural Killer Cells
Primates
HIV-1
Mucous Membrane
Up-Regulation
History
T-Lymphocytes
Research
Population

Keywords

  • Acute HIV infection
  • Chronic HIV infection
  • HIV
  • IFN
  • ISG
  • SIV
  • Type I interferon

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Type I Interferon : Understanding Its Role in HIV Pathogenesis and Therapy. / Bosinger, Steven E.; Utay, Netanya S.

In: Current HIV/AIDS Reports, Vol. 12, No. 1, 2015, p. 41-53.

Research output: Contribution to journalArticle

Bosinger, Steven E. ; Utay, Netanya S. / Type I Interferon : Understanding Its Role in HIV Pathogenesis and Therapy. In: Current HIV/AIDS Reports. 2015 ; Vol. 12, No. 1. pp. 41-53.
@article{1bdfa7e82404404a83c7308a6c57b35e,
title = "Type I Interferon: Understanding Its Role in HIV Pathogenesis and Therapy",
abstract = "Despite over 30 years of research, the contribution of type I interferons (IFN-Is) to both the control of HIV replication and initiation of immunologic damage remains debated. In acute infection, IFN-Is, likely from plasmacytoid dendritic cells (pDCs), activate NK cells and upregulate restriction factors targeting virtually the entire HIV life cycle. In chronic infection, IFN-Is may also contribute to CD4 T cell loss and immune exhaustion. pDCs subsequently infiltrate lymphoid and mucosal tissues, and their circulating populations wane in chronic infection; IFN-I may be produced by other cells. Data from nonhuman primates indicate prompt IFN-I signaling is critical in acute infection. Whereas some studies showed IFN-I administration without combination antiretroviral therapy (cART) is beneficial, others suggest that stimulating or blocking IFN-I signaling in chronic ART-suppressed HIV infection has had positive results. Here, we describe the history of HIV and IFN-I, IFN-I’s sources, IFN-I’s effects on HIV control and host defense, and recent interventional studies in SIV and HIV infection.",
keywords = "Acute HIV infection, Chronic HIV infection, HIV, IFN, ISG, SIV, Type I interferon",
author = "Bosinger, {Steven E.} and Utay, {Netanya S.}",
year = "2015",
doi = "10.1007/s11904-014-0244-6",
language = "English (US)",
volume = "12",
pages = "41--53",
journal = "Current HIV/AIDS Reports",
issn = "1548-3568",
publisher = "Current Science, Inc.",
number = "1",

}

TY - JOUR

T1 - Type I Interferon

T2 - Understanding Its Role in HIV Pathogenesis and Therapy

AU - Bosinger, Steven E.

AU - Utay, Netanya S.

PY - 2015

Y1 - 2015

N2 - Despite over 30 years of research, the contribution of type I interferons (IFN-Is) to both the control of HIV replication and initiation of immunologic damage remains debated. In acute infection, IFN-Is, likely from plasmacytoid dendritic cells (pDCs), activate NK cells and upregulate restriction factors targeting virtually the entire HIV life cycle. In chronic infection, IFN-Is may also contribute to CD4 T cell loss and immune exhaustion. pDCs subsequently infiltrate lymphoid and mucosal tissues, and their circulating populations wane in chronic infection; IFN-I may be produced by other cells. Data from nonhuman primates indicate prompt IFN-I signaling is critical in acute infection. Whereas some studies showed IFN-I administration without combination antiretroviral therapy (cART) is beneficial, others suggest that stimulating or blocking IFN-I signaling in chronic ART-suppressed HIV infection has had positive results. Here, we describe the history of HIV and IFN-I, IFN-I’s sources, IFN-I’s effects on HIV control and host defense, and recent interventional studies in SIV and HIV infection.

AB - Despite over 30 years of research, the contribution of type I interferons (IFN-Is) to both the control of HIV replication and initiation of immunologic damage remains debated. In acute infection, IFN-Is, likely from plasmacytoid dendritic cells (pDCs), activate NK cells and upregulate restriction factors targeting virtually the entire HIV life cycle. In chronic infection, IFN-Is may also contribute to CD4 T cell loss and immune exhaustion. pDCs subsequently infiltrate lymphoid and mucosal tissues, and their circulating populations wane in chronic infection; IFN-I may be produced by other cells. Data from nonhuman primates indicate prompt IFN-I signaling is critical in acute infection. Whereas some studies showed IFN-I administration without combination antiretroviral therapy (cART) is beneficial, others suggest that stimulating or blocking IFN-I signaling in chronic ART-suppressed HIV infection has had positive results. Here, we describe the history of HIV and IFN-I, IFN-I’s sources, IFN-I’s effects on HIV control and host defense, and recent interventional studies in SIV and HIV infection.

KW - Acute HIV infection

KW - Chronic HIV infection

KW - HIV

KW - IFN

KW - ISG

KW - SIV

KW - Type I interferon

UR - http://www.scopus.com/inward/record.url?scp=84925483168&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84925483168&partnerID=8YFLogxK

U2 - 10.1007/s11904-014-0244-6

DO - 10.1007/s11904-014-0244-6

M3 - Article

C2 - 25662992

AN - SCOPUS:84925483168

VL - 12

SP - 41

EP - 53

JO - Current HIV/AIDS Reports

JF - Current HIV/AIDS Reports

SN - 1548-3568

IS - 1

ER -