TY - JOUR
T1 - Type I Interferon
T2 - Understanding Its Role in HIV Pathogenesis and Therapy
AU - Bosinger, Steven E.
AU - Utay, Netanya S.
N1 - Publisher Copyright:
© 2015, Springer Science+Business Media New York.
PY - 2015/3/22
Y1 - 2015/3/22
N2 - Despite over 30 years of research, the contribution of type I interferons (IFN-Is) to both the control of HIV replication and initiation of immunologic damage remains debated. In acute infection, IFN-Is, likely from plasmacytoid dendritic cells (pDCs), activate NK cells and upregulate restriction factors targeting virtually the entire HIV life cycle. In chronic infection, IFN-Is may also contribute to CD4 T cell loss and immune exhaustion. pDCs subsequently infiltrate lymphoid and mucosal tissues, and their circulating populations wane in chronic infection; IFN-I may be produced by other cells. Data from nonhuman primates indicate prompt IFN-I signaling is critical in acute infection. Whereas some studies showed IFN-I administration without combination antiretroviral therapy (cART) is beneficial, others suggest that stimulating or blocking IFN-I signaling in chronic ART-suppressed HIV infection has had positive results. Here, we describe the history of HIV and IFN-I, IFN-I’s sources, IFN-I’s effects on HIV control and host defense, and recent interventional studies in SIV and HIV infection.
AB - Despite over 30 years of research, the contribution of type I interferons (IFN-Is) to both the control of HIV replication and initiation of immunologic damage remains debated. In acute infection, IFN-Is, likely from plasmacytoid dendritic cells (pDCs), activate NK cells and upregulate restriction factors targeting virtually the entire HIV life cycle. In chronic infection, IFN-Is may also contribute to CD4 T cell loss and immune exhaustion. pDCs subsequently infiltrate lymphoid and mucosal tissues, and their circulating populations wane in chronic infection; IFN-I may be produced by other cells. Data from nonhuman primates indicate prompt IFN-I signaling is critical in acute infection. Whereas some studies showed IFN-I administration without combination antiretroviral therapy (cART) is beneficial, others suggest that stimulating or blocking IFN-I signaling in chronic ART-suppressed HIV infection has had positive results. Here, we describe the history of HIV and IFN-I, IFN-I’s sources, IFN-I’s effects on HIV control and host defense, and recent interventional studies in SIV and HIV infection.
KW - Acute HIV infection
KW - Chronic HIV infection
KW - HIV
KW - IFN
KW - ISG
KW - SIV
KW - Type I interferon
UR - http://www.scopus.com/inward/record.url?scp=84925483168&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84925483168&partnerID=8YFLogxK
U2 - 10.1007/s11904-014-0244-6
DO - 10.1007/s11904-014-0244-6
M3 - Review article
C2 - 25662992
AN - SCOPUS:84925483168
SN - 1548-3568
VL - 12
SP - 41
EP - 53
JO - Current HIV/AIDS Reports
JF - Current HIV/AIDS Reports
IS - 1
ER -