Ubiquilin-1 regulates amyloid precursor protein maturation and degradation by stimulating K63-linked polyubiquitination of lysine 688

Keyphrases

• Amyloid Precursor Protein 100%
• Protein Degradation 100%
• Lysine 100%
• K63-linked Polyubiquitination 100%
• Protein Maturation 100%
• Ubiquilin 100%
• Secretase 37%
• Alzheimer's Disease 25%
• Proteolytic Processing 25%
• Late-onset Alzheimer's Disease 25%
• Peptide Fragments 12%
• Sequestration 12%
• Amyloidogenic Processing 12%
• Single nucleotide Polymorphism 12%
• Intracellular Localization 12%
• Protein Drug 12%
• Sequester 12%
• Amyloidogenic Peptides 12%
• Golgi Apparatus 12%
• Cytotoxic Peptide 12%
• Family Forms 12%
• Sporadic Form 12%
• Amyloid Precursor Protein Intracellular Domain 12%
• UBQLN1 12%
• Early Secretory Pathway 12%

Biochemistry, Genetics and Molecular Biology

• Posttranslational Modification 100%
• Protein Catabolism 100%
• Amyloid Precursor Protein 100%
• Lysine 100%
• Secretase 33%
• Maturation 22%
• Proteolytic Processing 22%
• Enzyme 11%
• Proteasome 11%
• Single-Nucleotide Polymorphism 11%
• Golgi Apparatus 11%
• Secretory Pathway 11%