Ultrasound-enhanced drug delivery for efficient cancer therapy

I. V. Larina, B. M. Evers, C. Bartels, T. V. Ashitkov, K. V. Larin, Rinat Esenaliev

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Citations (Scopus)

Abstract

Poor penetration of anti-cancer drugs through tumor vasculature and cancer cell membrane as well as slow diffusion of the drugs in the interstitium limit efficacy of cancer chemo- and biotherapy. Recently we proposed to use ultrasound-induced cavitation (formation, growth, and collapse of microbubbles) to enhance anti-cancer drug delivery through these barriers. Cavitation can be selectively induced in tumors by using interaction of ultrasound with nanoparticles that lower cavitation threshold and can be accumulated in tumors. In this paper, we measured cavitation threshold in water suspensions of polymer (polystyrene) nanoparticles and studied efficacy of cancer therapy in nude mice with the use of this technique. Experiments were performed at different irradiation conditions and concentration and size of nanoparticles. In vivo studies were conducted in nude mice bearing human colon (KM20) tumors at optimum conditions found in the experiments in water suspensions. Our studies demonstrated that: (1) polystyrene nanoparticles decrease cavitation threshold in water; and (2) application of this drug delivery technique substantially improve the efficacy of cancer therapy in nude mice when ultrasound was used in combination with polymer nanoparticle injections. Our results suggest that the ultrasound-induced cavitation enhances drug delivery in tumors and may provide efficient cancer chemo- and biotherapy.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Pages492-493
Number of pages2
Volume1
StatePublished - 2002
EventProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States
Duration: Oct 23 2002Oct 26 2002

Other

OtherProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS)
CountryUnited States
CityHouston, TX
Period10/23/0210/26/02

Fingerprint

Drug delivery
Cavitation
Ultrasonics
Tumors
Nanoparticles
Chemotherapy
Polystyrenes
Water
Suspensions
Polymers
Bearings (structural)
Cell membranes
Pharmaceutical Preparations
Experiments
Irradiation

Keywords

  • Drug delivery
  • Nanoparticle
  • Ultrasound

ASJC Scopus subject areas

  • Bioengineering

Cite this

Larina, I. V., Evers, B. M., Bartels, C., Ashitkov, T. V., Larin, K. V., & Esenaliev, R. (2002). Ultrasound-enhanced drug delivery for efficient cancer therapy. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 1, pp. 492-493)

Ultrasound-enhanced drug delivery for efficient cancer therapy. / Larina, I. V.; Evers, B. M.; Bartels, C.; Ashitkov, T. V.; Larin, K. V.; Esenaliev, Rinat.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 1 2002. p. 492-493.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Larina, IV, Evers, BM, Bartels, C, Ashitkov, TV, Larin, KV & Esenaliev, R 2002, Ultrasound-enhanced drug delivery for efficient cancer therapy. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. vol. 1, pp. 492-493, Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS), Houston, TX, United States, 10/23/02.
Larina IV, Evers BM, Bartels C, Ashitkov TV, Larin KV, Esenaliev R. Ultrasound-enhanced drug delivery for efficient cancer therapy. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 1. 2002. p. 492-493
Larina, I. V. ; Evers, B. M. ; Bartels, C. ; Ashitkov, T. V. ; Larin, K. V. ; Esenaliev, Rinat. / Ultrasound-enhanced drug delivery for efficient cancer therapy. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 1 2002. pp. 492-493
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