Ultrasound-guided cardiac blood sampling of the rabbit fetus

K. J. Moise, George Saade, L. Knudsen, A. Valdez-Torres, M. A. Belfort, H. Hsu, S. C. Harvey, K. M. Hudson, L. S. Rodkey

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The object of the study was to determine whether cardiac sampling of the rabbit fetus could be successfully accomplished with minimal procedure-related loss. Pregnant rabbit dams were randomized to undergo ultrasound-guided fetal cardiac sampling in either the left or right uterine horn at 27 days of gestation; cesarean delivery was performed the following day. Liveborn pups from unsampled uterine horns underwent cardiac puncture immediately after birth. Fetal hematologic parameters were then compared to neonatal parameters. The acute fetal mortality from the sampled uterine horns was similar to that of the unsampled horns (3.6 vs. 4.5%). Fetal hematologic values were significantly higher than neonatal values with the exception of the reticulocyte count. This rabbit model offers a new approach for the evaluation of novel treatment modalities for hemolytic disease of the human fetus.

Original languageEnglish (US)
Pages (from-to)331-336
Number of pages6
JournalFetal Diagnosis and Therapy
Volume9
Issue number5
StatePublished - 1994
Externally publishedYes

Fingerprint

Fetus
Rabbits
Reticulocyte Count
Fetal Mortality
Horns
Punctures
Parturition
Pregnancy
Therapeutics

Keywords

  • hemolytic disease of the newborn
  • percutaneous umbilical blood sampling
  • rhesus alloimmunization

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

Cite this

Moise, K. J., Saade, G., Knudsen, L., Valdez-Torres, A., Belfort, M. A., Hsu, H., ... Rodkey, L. S. (1994). Ultrasound-guided cardiac blood sampling of the rabbit fetus. Fetal Diagnosis and Therapy, 9(5), 331-336.

Ultrasound-guided cardiac blood sampling of the rabbit fetus. / Moise, K. J.; Saade, George; Knudsen, L.; Valdez-Torres, A.; Belfort, M. A.; Hsu, H.; Harvey, S. C.; Hudson, K. M.; Rodkey, L. S.

In: Fetal Diagnosis and Therapy, Vol. 9, No. 5, 1994, p. 331-336.

Research output: Contribution to journalArticle

Moise, KJ, Saade, G, Knudsen, L, Valdez-Torres, A, Belfort, MA, Hsu, H, Harvey, SC, Hudson, KM & Rodkey, LS 1994, 'Ultrasound-guided cardiac blood sampling of the rabbit fetus', Fetal Diagnosis and Therapy, vol. 9, no. 5, pp. 331-336.
Moise KJ, Saade G, Knudsen L, Valdez-Torres A, Belfort MA, Hsu H et al. Ultrasound-guided cardiac blood sampling of the rabbit fetus. Fetal Diagnosis and Therapy. 1994;9(5):331-336.
Moise, K. J. ; Saade, George ; Knudsen, L. ; Valdez-Torres, A. ; Belfort, M. A. ; Hsu, H. ; Harvey, S. C. ; Hudson, K. M. ; Rodkey, L. S. / Ultrasound-guided cardiac blood sampling of the rabbit fetus. In: Fetal Diagnosis and Therapy. 1994 ; Vol. 9, No. 5. pp. 331-336.
@article{55b4e01a781e456f98de3c3ca40263e7,
title = "Ultrasound-guided cardiac blood sampling of the rabbit fetus",
abstract = "The object of the study was to determine whether cardiac sampling of the rabbit fetus could be successfully accomplished with minimal procedure-related loss. Pregnant rabbit dams were randomized to undergo ultrasound-guided fetal cardiac sampling in either the left or right uterine horn at 27 days of gestation; cesarean delivery was performed the following day. Liveborn pups from unsampled uterine horns underwent cardiac puncture immediately after birth. Fetal hematologic parameters were then compared to neonatal parameters. The acute fetal mortality from the sampled uterine horns was similar to that of the unsampled horns (3.6 vs. 4.5{\%}). Fetal hematologic values were significantly higher than neonatal values with the exception of the reticulocyte count. This rabbit model offers a new approach for the evaluation of novel treatment modalities for hemolytic disease of the human fetus.",
keywords = "hemolytic disease of the newborn, percutaneous umbilical blood sampling, rhesus alloimmunization",
author = "Moise, {K. J.} and George Saade and L. Knudsen and A. Valdez-Torres and Belfort, {M. A.} and H. Hsu and Harvey, {S. C.} and Hudson, {K. M.} and Rodkey, {L. S.}",
year = "1994",
language = "English (US)",
volume = "9",
pages = "331--336",
journal = "Fetal Diagnosis and Therapy",
issn = "1015-3837",
publisher = "S. Karger AG",
number = "5",

}

TY - JOUR

T1 - Ultrasound-guided cardiac blood sampling of the rabbit fetus

AU - Moise, K. J.

AU - Saade, George

AU - Knudsen, L.

AU - Valdez-Torres, A.

AU - Belfort, M. A.

AU - Hsu, H.

AU - Harvey, S. C.

AU - Hudson, K. M.

AU - Rodkey, L. S.

PY - 1994

Y1 - 1994

N2 - The object of the study was to determine whether cardiac sampling of the rabbit fetus could be successfully accomplished with minimal procedure-related loss. Pregnant rabbit dams were randomized to undergo ultrasound-guided fetal cardiac sampling in either the left or right uterine horn at 27 days of gestation; cesarean delivery was performed the following day. Liveborn pups from unsampled uterine horns underwent cardiac puncture immediately after birth. Fetal hematologic parameters were then compared to neonatal parameters. The acute fetal mortality from the sampled uterine horns was similar to that of the unsampled horns (3.6 vs. 4.5%). Fetal hematologic values were significantly higher than neonatal values with the exception of the reticulocyte count. This rabbit model offers a new approach for the evaluation of novel treatment modalities for hemolytic disease of the human fetus.

AB - The object of the study was to determine whether cardiac sampling of the rabbit fetus could be successfully accomplished with minimal procedure-related loss. Pregnant rabbit dams were randomized to undergo ultrasound-guided fetal cardiac sampling in either the left or right uterine horn at 27 days of gestation; cesarean delivery was performed the following day. Liveborn pups from unsampled uterine horns underwent cardiac puncture immediately after birth. Fetal hematologic parameters were then compared to neonatal parameters. The acute fetal mortality from the sampled uterine horns was similar to that of the unsampled horns (3.6 vs. 4.5%). Fetal hematologic values were significantly higher than neonatal values with the exception of the reticulocyte count. This rabbit model offers a new approach for the evaluation of novel treatment modalities for hemolytic disease of the human fetus.

KW - hemolytic disease of the newborn

KW - percutaneous umbilical blood sampling

KW - rhesus alloimmunization

UR - http://www.scopus.com/inward/record.url?scp=0028137151&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028137151&partnerID=8YFLogxK

M3 - Article

C2 - 7818782

AN - SCOPUS:0028137151

VL - 9

SP - 331

EP - 336

JO - Fetal Diagnosis and Therapy

JF - Fetal Diagnosis and Therapy

SN - 1015-3837

IS - 5

ER -