Ultrastructural alterations in allylamine cardiovascular toxicity. Late myocardial and vascular lesions

P. J. Boor, V. J. Ferrans

Research output: Contribution to journalArticle

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Abstract

The late myocardial and vascular ultrastructural changes in rat hearts following consumption of the cardiovascular toxin allylamine were studied. Rats were given 0.1% allylamine HCl in drinking water for 10-104 days. From 10 to 21 days, there was organization of acute myocardial necrosis by macrophages and scattered polymorphonuclear leukocytes with prominent interstitial-cell proliferation. Alterations at 21-104 days included extensive scarring with formation of dense mature collagen with scattered fibroblasts present, grossly evident left-ventricular aneurysm, and gross and microscopic changes similar to those observed in the secondary form of endocardial fibroelastosis. Areas of scar contained highly cellular foci of smooth-muscle cells, myofibroblasts, and abundant extracellular elastin. Cardiac myocytes frequently showed markedly disorganized myofilaments, bizarrely distorted mitochondria with condensed cristae, and other severe degenerative changes. Small vessels within and adjacent to scar showed proliferation of intimal smooth-muscle cells. Endothelial lesions or recent or organized thrombi were not seen. Focal endothelial metaplasia, consisting of both chondroid and osseous tissue, was found in areas of transmural scarring, or ventricular aneurysm. Chondrocytes had the overall nuclear and cellular morphology, abundant rough endoplasmic reticulum, and surrounding lacunae typical of mature fibrocartilage. In some areas, the collagen matrix was undergoing calcification with the typical cross-banded pattern of calcifying connective tissue. Osteocytes were located in a densely calcified bone matrix and displayed characteristic cellular extensions into surrounding canaliculi. These findings indicate a severe myocardial, small-vessel, and endocardial injury during the course of chronic allylamine intoxication.

Original languageEnglish (US)
Pages (from-to)39-54
Number of pages16
JournalAmerican Journal of Pathology
Volume121
Issue number1
StatePublished - 1985

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Allylamine
Cicatrix
Blood Vessels
Smooth Muscle Myocytes
Aneurysm
Collagen
Endocardial Fibroelastosis
Fibrocartilage
Tunica Intima
Osteocytes
Bone Matrix
Myofibroblasts
Elastin
Rough Endoplasmic Reticulum
Myofibrils
Metaplasia
Chondrocytes
Cardiac Myocytes
Drinking Water
Connective Tissue

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Ultrastructural alterations in allylamine cardiovascular toxicity. Late myocardial and vascular lesions. / Boor, P. J.; Ferrans, V. J.

In: American Journal of Pathology, Vol. 121, No. 1, 1985, p. 39-54.

Research output: Contribution to journalArticle

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