Ultrastructural and immunohistochemical evidence for release of eosinophilic granules in vivo

Cytotoxic potential in chronic eosinophilic pneumonia

Emilio Gonzalez, John L. Swedo, Srinivasan Rajaraman, Jerry C. Daniels, J. Andrew Grant

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We studied a patient with relapsing idiopathic chronic eosinophilic pneumonia. Each one of four attacks observed during a 4-year period was characterized by dyspnea, wheezing, peripheral blood eosinophilia, elevated serum IgE levels, and pulmonary infiltrates. Glucocorticoid therapy caused prompt resolution of symptoms and disappearance of blood eosinophilia and pulmonary shadowing. Electron microscopy and tissue immunofluorescence studies for major basic protein documented extensive eosinophil degranulation and the presence of free granules within the pulmonary microvasculature. In addition, exfoliation of the alveolar lining cell was observed in association with a clustering of free intact and disintegrating extracellular eosinophil granules against a denuded basement membrane. These findings suggest a cytotoxic potential of the eosinophil at the level of the pulmonary parenchyma in a case of idiopathic chronic eosinophilic pneumonia.

Original languageEnglish (US)
Pages (from-to)755-762
Number of pages8
JournalThe Journal of Allergy and Clinical Immunology
Volume79
Issue number5
DOIs
StatePublished - 1987

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Eosinophils
Lung
Pulmonary Eosinophilia
Alveolar Epithelial Cells
Respiratory Sounds
Eosinophilia
Microvessels
Basement Membrane
Dyspnea
Immunoglobulin E
Glucocorticoids
Fluorescent Antibody Technique
Cluster Analysis
Electron Microscopy
Serum
Carrington syndrome
Proteins
Therapeutics

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Ultrastructural and immunohistochemical evidence for release of eosinophilic granules in vivo : Cytotoxic potential in chronic eosinophilic pneumonia. / Gonzalez, Emilio; Swedo, John L.; Rajaraman, Srinivasan; Daniels, Jerry C.; Grant, J. Andrew.

In: The Journal of Allergy and Clinical Immunology, Vol. 79, No. 5, 1987, p. 755-762.

Research output: Contribution to journalArticle

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