Klamath virus was observed by negative contrast and thin section electron microscopy. Bullet-shaped particles in infected cell cultures had mean dimensions of 167×80 nm and were typical of members of the Rhabdovirus group. In infected mouse brain, virus particles budded from intracytoplasmic membranes in association with a prominent matrix. Although the virus is serologically unrelated to any of the known Rhabdoviruses of animals, this intracytoplasmic accumulation of virus particles and matrix with little frank cytopathology, most closely resembles in vivo rabies virus infection.
ASJC Scopus subject areas
- Applied Microbiology and Biotechnology