Ultrastructural pathology of coxsackie A4 virus infection of mouse striated muscle

Alyne K. Harrison, Frederick A. Murphy, G. William Gary

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Electron microscopic examination of Coxsackie A4 virus-infected hind limb muscles of suckling mice showed generalized myositis with almost total loss of normal muscle cell architecture. Degenerative changes included dilatation of sarcoplasmic reticulum with concurrent disruption of myofibrils, presenting the appearance of dense amorphous masses in some areas; large accumulations of membrane-bound vesicles; swelling, distortion, and mineralization of mitochondria; increase in lipid deposits; pyknosis of the nuclei; edema and inflammatory infiltration. Virus particles were present in a number of different configurations in muscle fibers: individual particles or small accumulations within vacuoles, two-dimensional linear arrays between membranes, and three-dimensional crystalline arrays, usually in close apposition to sarcoplasmic reticulum or sarcolemma.

Original languageEnglish (US)
Pages (from-to)30-42
Number of pages13
JournalExperimental and Molecular Pathology
Volume14
Issue number1
DOIs
StatePublished - 1971

Fingerprint

Coxsackievirus Infections
Striated Muscle
Sarcoplasmic Reticulum
Pathology
Viruses
Muscle
Muscles
Sarcolemma
Myositis
Membranes
Myofibrils
Enterovirus
Vacuoles
Virion
Muscle Cells
Dilatation
Edema
Mitochondria
Extremities
Electrons

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Biology
  • Pathology and Forensic Medicine

Cite this

Ultrastructural pathology of coxsackie A4 virus infection of mouse striated muscle. / Harrison, Alyne K.; Murphy, Frederick A.; William Gary, G.

In: Experimental and Molecular Pathology, Vol. 14, No. 1, 1971, p. 30-42.

Research output: Contribution to journalArticle

Harrison, Alyne K. ; Murphy, Frederick A. ; William Gary, G. / Ultrastructural pathology of coxsackie A4 virus infection of mouse striated muscle. In: Experimental and Molecular Pathology. 1971 ; Vol. 14, No. 1. pp. 30-42.
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