Umbilical cord blood biomarkers of neurologic injury and the risk of cerebral palsy or infant death

Maged Costantine, Steven J. Weiner, Dwight J. Rouse, Deborah G. Hirtz, Michael W. Varner, Catherine Y. Spong, Brian M. Mercer, Jay D. Iams, Ronald J. Wapner, Yoram Sorokin, John M. Thorp, Susan M. Ramin, Mary J. O'Sullivan, Alan M. Peaceman, Hyagriv N. Simhan

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

To evaluate the association between cerebral palsy (CP) or infant death and putative cord blood biomarkers of neurologic injury, we performed a nested case-control secondary analysis of a multicenter randomized trial of magnesium sulfate (MgSO 4) versus placebo to prevent CP or death among offspring of women with anticipated delivery from 24 to 31 weeks' gestation. Cases were infants who died by 1 year (n=25) or developed CP (n=16), and were matched 1:2 to a control group (n=82) that survived without developing CP. Umbilical cord sera concentrations of S100B, neuron-specific enolase (NSE) and the total soluble form of the receptor for advanced glycation end-products (sRAGE) were measured by ELISA in duplicates. Maternal characteristics were similar between the 2 groups. Cases were born at a lower gestational age (GA) and had lower birth weight compared with controls. There were no differences in concentrations of the three biomarkers and the composite outcome of CP or infant death. However, S100B was higher (median 847.3 vs. 495.7pg/ml; P=0.03) in infants who had CP and total sRAGE was lower (median 1259.3 vs. 1813.1pg/ml; P=0.02) in those who died compared with the control group. When corrected for delivery GA and treatment group, both differences lost statistical significance. In conclusion, cord blood S100B level may be associated with CP, but this association was not significant after controlling for GA and MgSO 4 treatment.

Original languageEnglish
Pages (from-to)917-922
Number of pages6
JournalInternational Journal of Developmental Neuroscience
Volume29
Issue number8
DOIs
StatePublished - Dec 2011

Fingerprint

Nervous System Trauma
Cerebral Palsy
Fetal Blood
Biomarkers
Gestational Age
Magnesium Sulfate
Control Groups
Phosphopyruvate Hydratase
Umbilical Cord
Infant Death
Birth Weight
Multicenter Studies
Age Groups
Enzyme-Linked Immunosorbent Assay
Placebos
Mothers
Pregnancy
Therapeutics
Serum

Keywords

  • Cerebral palsy
  • Infant death
  • Neuroprotection
  • Pregnancy
  • Umbilical cord biomarkers

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

Costantine, M., Weiner, S. J., Rouse, D. J., Hirtz, D. G., Varner, M. W., Spong, C. Y., ... Simhan, H. N. (2011). Umbilical cord blood biomarkers of neurologic injury and the risk of cerebral palsy or infant death. International Journal of Developmental Neuroscience, 29(8), 917-922. https://doi.org/10.1016/j.ijdevneu.2011.06.009

Umbilical cord blood biomarkers of neurologic injury and the risk of cerebral palsy or infant death. / Costantine, Maged; Weiner, Steven J.; Rouse, Dwight J.; Hirtz, Deborah G.; Varner, Michael W.; Spong, Catherine Y.; Mercer, Brian M.; Iams, Jay D.; Wapner, Ronald J.; Sorokin, Yoram; Thorp, John M.; Ramin, Susan M.; O'Sullivan, Mary J.; Peaceman, Alan M.; Simhan, Hyagriv N.

In: International Journal of Developmental Neuroscience, Vol. 29, No. 8, 12.2011, p. 917-922.

Research output: Contribution to journalArticle

Costantine, M, Weiner, SJ, Rouse, DJ, Hirtz, DG, Varner, MW, Spong, CY, Mercer, BM, Iams, JD, Wapner, RJ, Sorokin, Y, Thorp, JM, Ramin, SM, O'Sullivan, MJ, Peaceman, AM & Simhan, HN 2011, 'Umbilical cord blood biomarkers of neurologic injury and the risk of cerebral palsy or infant death', International Journal of Developmental Neuroscience, vol. 29, no. 8, pp. 917-922. https://doi.org/10.1016/j.ijdevneu.2011.06.009
Costantine, Maged ; Weiner, Steven J. ; Rouse, Dwight J. ; Hirtz, Deborah G. ; Varner, Michael W. ; Spong, Catherine Y. ; Mercer, Brian M. ; Iams, Jay D. ; Wapner, Ronald J. ; Sorokin, Yoram ; Thorp, John M. ; Ramin, Susan M. ; O'Sullivan, Mary J. ; Peaceman, Alan M. ; Simhan, Hyagriv N. / Umbilical cord blood biomarkers of neurologic injury and the risk of cerebral palsy or infant death. In: International Journal of Developmental Neuroscience. 2011 ; Vol. 29, No. 8. pp. 917-922.
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