Umbilical cord blood markers of oxidative stress in pregnancies complicated by preterm prelabor rupture of membranes

Ivana Musilova, Lubomira Tothova, Ramkumar Menon, Barbora Vlkova, Peter Celec, Helena Hornychova, Radka Kutova, Ctirad Andrys, Martin Stepan, Marian Kacerovsky

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: To determine umbilical cord blood total antioxidant capacity (TAC), ferric reducing antioxidant power (FRAP), thiobarbituric acid-reacting substances (TBARS), advanced glycation end products (AGEs) and markers of oxidative stress in pregnancies complicated by preterm prelabor rupture of membranes (PPROM) and their associations with microbial invasion of the amniotic cavity (MIAC) and/or histological chorioamnionitis (HCA), funisitis and selected aspects of short-term neonatal morbidity. Materials and methods: One hundred and sixty-five women with singleton pregnancies complicated by PPROM were included in this study. Blood samples were obtained by venipuncture from the umbilical cord vein after the delivery of the newborn. The umbilical cord blood concentrations of TAC, FRAP, TBARS and AGEs were measured. Results: The presence of MIAC, HCA and funisitis did not show differences in the umbilical cord blood TAC, FRAP, TBARS and AGEs concentrations. Positive correlations were found between the gestational age at sampling and umbilical cord blood TAC and AGEs concentrations (TAC: rho = 0.26; p = 0.001; AGEs: rho = 0.35; p < 0.0001). There was no association between umbilical cord blood TAC, FRAP, TBARS and AGEs concentrations and selected aspects of short-term neonatal morbidity. Conclusions: Oxidative stress is associated with PPROM, as indicated by the presence of markers tested in the umbilical cord blood; however, the evaluated oxidative stress markers are not influenced by the presence of MIAC and/or HCA, and funisitis or subsequent development of selected aspects of short-term neonatal morbidity.

Original languageEnglish (US)
JournalJournal of Maternal-Fetal and Neonatal Medicine
DOIs
StateAccepted/In press - Aug 20 2015

Fingerprint

Fetal Blood
Rupture
Oxidative Stress
Chorioamnionitis
Antioxidants
Pregnancy
Membranes
Morbidity
Umbilical Veins
Advanced Glycosylation End Products
Phlebotomy
Umbilical Cord
Gestational Age
Newborn Infant
thiobarbituric acid

Keywords

  • Advanced glycation end products
  • ferric reducing antioxidant power
  • histological chorioamnionitis
  • microbial invasion of the amniotic cavity
  • preterm delivery
  • rupture of membranes
  • thiobarbituric acid-reacting substances
  • total antioxidant capacity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Umbilical cord blood markers of oxidative stress in pregnancies complicated by preterm prelabor rupture of membranes. / Musilova, Ivana; Tothova, Lubomira; Menon, Ramkumar; Vlkova, Barbora; Celec, Peter; Hornychova, Helena; Kutova, Radka; Andrys, Ctirad; Stepan, Martin; Kacerovsky, Marian.

In: Journal of Maternal-Fetal and Neonatal Medicine, 20.08.2015.

Research output: Contribution to journalArticle

Musilova, Ivana ; Tothova, Lubomira ; Menon, Ramkumar ; Vlkova, Barbora ; Celec, Peter ; Hornychova, Helena ; Kutova, Radka ; Andrys, Ctirad ; Stepan, Martin ; Kacerovsky, Marian. / Umbilical cord blood markers of oxidative stress in pregnancies complicated by preterm prelabor rupture of membranes. In: Journal of Maternal-Fetal and Neonatal Medicine. 2015.
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abstract = "Objective: To determine umbilical cord blood total antioxidant capacity (TAC), ferric reducing antioxidant power (FRAP), thiobarbituric acid-reacting substances (TBARS), advanced glycation end products (AGEs) and markers of oxidative stress in pregnancies complicated by preterm prelabor rupture of membranes (PPROM) and their associations with microbial invasion of the amniotic cavity (MIAC) and/or histological chorioamnionitis (HCA), funisitis and selected aspects of short-term neonatal morbidity. Materials and methods: One hundred and sixty-five women with singleton pregnancies complicated by PPROM were included in this study. Blood samples were obtained by venipuncture from the umbilical cord vein after the delivery of the newborn. The umbilical cord blood concentrations of TAC, FRAP, TBARS and AGEs were measured. Results: The presence of MIAC, HCA and funisitis did not show differences in the umbilical cord blood TAC, FRAP, TBARS and AGEs concentrations. Positive correlations were found between the gestational age at sampling and umbilical cord blood TAC and AGEs concentrations (TAC: rho = 0.26; p = 0.001; AGEs: rho = 0.35; p < 0.0001). There was no association between umbilical cord blood TAC, FRAP, TBARS and AGEs concentrations and selected aspects of short-term neonatal morbidity. Conclusions: Oxidative stress is associated with PPROM, as indicated by the presence of markers tested in the umbilical cord blood; however, the evaluated oxidative stress markers are not influenced by the presence of MIAC and/or HCA, and funisitis or subsequent development of selected aspects of short-term neonatal morbidity.",
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T1 - Umbilical cord blood markers of oxidative stress in pregnancies complicated by preterm prelabor rupture of membranes

AU - Musilova, Ivana

AU - Tothova, Lubomira

AU - Menon, Ramkumar

AU - Vlkova, Barbora

AU - Celec, Peter

AU - Hornychova, Helena

AU - Kutova, Radka

AU - Andrys, Ctirad

AU - Stepan, Martin

AU - Kacerovsky, Marian

PY - 2015/8/20

Y1 - 2015/8/20

N2 - Objective: To determine umbilical cord blood total antioxidant capacity (TAC), ferric reducing antioxidant power (FRAP), thiobarbituric acid-reacting substances (TBARS), advanced glycation end products (AGEs) and markers of oxidative stress in pregnancies complicated by preterm prelabor rupture of membranes (PPROM) and their associations with microbial invasion of the amniotic cavity (MIAC) and/or histological chorioamnionitis (HCA), funisitis and selected aspects of short-term neonatal morbidity. Materials and methods: One hundred and sixty-five women with singleton pregnancies complicated by PPROM were included in this study. Blood samples were obtained by venipuncture from the umbilical cord vein after the delivery of the newborn. The umbilical cord blood concentrations of TAC, FRAP, TBARS and AGEs were measured. Results: The presence of MIAC, HCA and funisitis did not show differences in the umbilical cord blood TAC, FRAP, TBARS and AGEs concentrations. Positive correlations were found between the gestational age at sampling and umbilical cord blood TAC and AGEs concentrations (TAC: rho = 0.26; p = 0.001; AGEs: rho = 0.35; p < 0.0001). There was no association between umbilical cord blood TAC, FRAP, TBARS and AGEs concentrations and selected aspects of short-term neonatal morbidity. Conclusions: Oxidative stress is associated with PPROM, as indicated by the presence of markers tested in the umbilical cord blood; however, the evaluated oxidative stress markers are not influenced by the presence of MIAC and/or HCA, and funisitis or subsequent development of selected aspects of short-term neonatal morbidity.

AB - Objective: To determine umbilical cord blood total antioxidant capacity (TAC), ferric reducing antioxidant power (FRAP), thiobarbituric acid-reacting substances (TBARS), advanced glycation end products (AGEs) and markers of oxidative stress in pregnancies complicated by preterm prelabor rupture of membranes (PPROM) and their associations with microbial invasion of the amniotic cavity (MIAC) and/or histological chorioamnionitis (HCA), funisitis and selected aspects of short-term neonatal morbidity. Materials and methods: One hundred and sixty-five women with singleton pregnancies complicated by PPROM were included in this study. Blood samples were obtained by venipuncture from the umbilical cord vein after the delivery of the newborn. The umbilical cord blood concentrations of TAC, FRAP, TBARS and AGEs were measured. Results: The presence of MIAC, HCA and funisitis did not show differences in the umbilical cord blood TAC, FRAP, TBARS and AGEs concentrations. Positive correlations were found between the gestational age at sampling and umbilical cord blood TAC and AGEs concentrations (TAC: rho = 0.26; p = 0.001; AGEs: rho = 0.35; p < 0.0001). There was no association between umbilical cord blood TAC, FRAP, TBARS and AGEs concentrations and selected aspects of short-term neonatal morbidity. Conclusions: Oxidative stress is associated with PPROM, as indicated by the presence of markers tested in the umbilical cord blood; however, the evaluated oxidative stress markers are not influenced by the presence of MIAC and/or HCA, and funisitis or subsequent development of selected aspects of short-term neonatal morbidity.

KW - Advanced glycation end products

KW - ferric reducing antioxidant power

KW - histological chorioamnionitis

KW - microbial invasion of the amniotic cavity

KW - preterm delivery

KW - rupture of membranes

KW - thiobarbituric acid-reacting substances

KW - total antioxidant capacity

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DO - 10.3109/14767058.2015.1074997

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JO - Journal of Maternal-Fetal and Neonatal Medicine

JF - Journal of Maternal-Fetal and Neonatal Medicine

SN - 1476-7058

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