Understanding biology by stretching proteins

recent progress

Albert Galera-Prat, Angel Gómez-Sicilia, Andres Oberhauser, Marek Cieplak, Mariano Carrión-Vázquez

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Single molecule manipulation techniques combined with molecular dynamics simulations and protein engineering have enabled, during the last decade, the mechanical properties of proteins to be studied directly, thereby giving birth to the field of protein nanomechanics. Recent data obtained from such techniques have helped gain insight into the structural bases of protein resistance against forced unfolding, as well as revealing structural motifs involved in mechanical stability. Also, important technical developments have provided new perspectives into protein folding. Eventually, new and exciting data have shown that mechanical properties are key factors in cell signaling and pathologies, and have been used to rationally tune these properties in a variety of proteins. Crown

Original languageEnglish (US)
Pages (from-to)63-69
Number of pages7
JournalCurrent Opinion in Structural Biology
Volume20
Issue number1
DOIs
StatePublished - Feb 2010

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Proteins
Protein Engineering
Protein Folding
Molecular Dynamics Simulation
Crowns
Parturition
Pathology

ASJC Scopus subject areas

  • Molecular Biology
  • Structural Biology

Cite this

Understanding biology by stretching proteins : recent progress. / Galera-Prat, Albert; Gómez-Sicilia, Angel; Oberhauser, Andres; Cieplak, Marek; Carrión-Vázquez, Mariano.

In: Current Opinion in Structural Biology, Vol. 20, No. 1, 02.2010, p. 63-69.

Research output: Contribution to journalArticle

Galera-Prat, A, Gómez-Sicilia, A, Oberhauser, A, Cieplak, M & Carrión-Vázquez, M 2010, 'Understanding biology by stretching proteins: recent progress', Current Opinion in Structural Biology, vol. 20, no. 1, pp. 63-69. https://doi.org/10.1016/j.sbi.2010.01.003
Galera-Prat, Albert ; Gómez-Sicilia, Angel ; Oberhauser, Andres ; Cieplak, Marek ; Carrión-Vázquez, Mariano. / Understanding biology by stretching proteins : recent progress. In: Current Opinion in Structural Biology. 2010 ; Vol. 20, No. 1. pp. 63-69.
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