TY - JOUR
T1 - Understanding the language of Lys36 methylation at histone H3
AU - Wagner, Eric J.
AU - Carpenter, Phillip B.
N1 - Funding Information:
We apologize to those researchers whose work could not be cited owing to space constraints. We thank B. Martinez and K. Eterovic for assistance with the figures, as well as S. Ercan, P. Masamha and A. Sataluri for critical comments regarding the manuscript. Work in the laboratory of P.B.C. has been supported in part by the Robert A. Welch Foundation (AU-1569). Work in the laboratory of E.J.W. is supported by the US National Institutes of Health (5R00GM080447).
PY - 2012/2
Y1 - 2012/2
N2 - Histone side chains are post-translationally modified at multiple sites, including at Lys36 on histone H3 (H3K36). Several enzymes from yeast and humans, including the methyltransferases SET domain-containing 2 (Set2) and nuclear receptor SET domain-containing 1 (NSD1), respectively, alter the methylation status of H3K36, and significant progress has been made in understanding how they affect chromatin structure and function. Although H3K36 methylation is most commonly associated with the transcription of active euchromatin, it has also been implicated in diverse processes, including alternative splicing, dosage compensation and transcriptional repression, as well as DNA repair and recombination. Disrupted placement of methylated H3K36 within the chromatin landscape can lead to a range of human diseases, underscoring the importance of this modification.
AB - Histone side chains are post-translationally modified at multiple sites, including at Lys36 on histone H3 (H3K36). Several enzymes from yeast and humans, including the methyltransferases SET domain-containing 2 (Set2) and nuclear receptor SET domain-containing 1 (NSD1), respectively, alter the methylation status of H3K36, and significant progress has been made in understanding how they affect chromatin structure and function. Although H3K36 methylation is most commonly associated with the transcription of active euchromatin, it has also been implicated in diverse processes, including alternative splicing, dosage compensation and transcriptional repression, as well as DNA repair and recombination. Disrupted placement of methylated H3K36 within the chromatin landscape can lead to a range of human diseases, underscoring the importance of this modification.
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U2 - 10.1038/nrm3274
DO - 10.1038/nrm3274
M3 - Review article
C2 - 22266761
AN - SCOPUS:84856120332
SN - 1471-0072
VL - 13
SP - 115
EP - 126
JO - Nature Reviews Molecular Cell Biology
JF - Nature Reviews Molecular Cell Biology
IS - 2
ER -