Understanding the role of aldose reductase in ocular inflammation

U. C S Yadav, Satish Srivastava, Kota Ramana

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Aldose reductase, although identified initially as a glucose-reducing enzyme via polyol pathway, is believed to be an important component of antioxidant defense system as well as a key mediator of oxidative stress-induced molecular signaling. The dual role played by AR has made it a very important enzyme for the regulation of not only the cellular redox state by detoxifying the reactive lipid-aldehydes generated by lipid peroxidation which is crucial in the cellular homeostasis, but also in the regulation of molecular signaling cascade that may regulate oxidative stress-induced cytotoxic events. Search for the new molecular targets to restrain the oxidative stress-induced inflammation has resulted in the identification of AR as an unanticipated mediator of oxidative stress-induced signaling. Although, in last one decade or so AR has been implicated in various inflammation-related disease conditions ranging from diabetes, sepsis, cancer, cardiovascular and airway inflammation, however, a critical evaluation of the clinical efficacy of AR inhibitors awaits a better understanding of the role of AR in regulating inflammation, especially in ocular inflammation.

Original languageEnglish (US)
Pages (from-to)540-549
Number of pages10
JournalCurrent Molecular Medicine
Volume10
Issue number6
StatePublished - 2010

Fingerprint

Aldehyde Reductase
Oxidative stress
Inflammation
Oxidative Stress
Lipids
Enzymes
Medical problems
Aldehydes
Antioxidants
Lipid Peroxidation
Oxidation-Reduction
Sepsis
Glucose
Homeostasis
Neoplasms

Keywords

  • Aldose reductase
  • Autoimmunity
  • GS-DHN
  • Infection
  • Inflammation
  • NF-κB
  • Uveitis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Molecular Medicine
  • Medicine(all)

Cite this

Understanding the role of aldose reductase in ocular inflammation. / Yadav, U. C S; Srivastava, Satish; Ramana, Kota.

In: Current Molecular Medicine, Vol. 10, No. 6, 2010, p. 540-549.

Research output: Contribution to journalArticle

Yadav, U. C S ; Srivastava, Satish ; Ramana, Kota. / Understanding the role of aldose reductase in ocular inflammation. In: Current Molecular Medicine. 2010 ; Vol. 10, No. 6. pp. 540-549.
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