Understanding the role of aldose reductase in ocular inflammation

U. C.S. Yadav, S. K. Srivastava, K. V. Ramana

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Aldose reductase, although identified initially as a glucose-reducing enzyme via polyol pathway, is believed to be an important component of antioxidant defense system as well as a key mediator of oxidative stress-induced molecular signaling. The dual role played by AR has made it a very important enzyme for the regulation of not only the cellular redox state by detoxifying the reactive lipid-aldehydes generated by lipid peroxidation which is crucial in the cellular homeostasis, but also in the regulation of molecular signaling cascade that may regulate oxidative stress-induced cytotoxic events. Search for the new molecular targets to restrain the oxidative stress-induced inflammation has resulted in the identification of AR as an unanticipated mediator of oxidative stress-induced signaling. Although, in last one decade or so AR has been implicated in various inflammation-related disease conditions ranging from diabetes, sepsis, cancer, cardiovascular and airway inflammation, however, a critical evaluation of the clinical efficacy of AR inhibitors awaits a better understanding of the role of AR in regulating inflammation, especially in ocular inflammation.

Original languageEnglish (US)
Pages (from-to)540-549
Number of pages10
JournalCurrent molecular medicine
Volume10
Issue number6
StatePublished - Jan 1 2010

Keywords

  • Aldose reductase
  • Autoimmunity
  • GS-DHN
  • Infection
  • Inflammation
  • NF-κB
  • Uveitis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology

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    Yadav, U. C. S., Srivastava, S. K., & Ramana, K. V. (2010). Understanding the role of aldose reductase in ocular inflammation. Current molecular medicine, 10(6), 540-549.