Unexpected growth-stimulatory effect of somatostatin analogue on cultured human pancreatic carcinoid cells

Jin Ishizuka, R. Daniel Beauchamp, B. Mark Evers, Courtney Townsend, James C. Thompson

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Therapeutic efficacy of a synthetic somatostatin analogue for the treatment of carcinoid tumors is still controversial. In vivo studies performed in our laboratory showed that a somatostatin analogue, SMS 201-995, significantly inhibited growth of human pancreatic carcinoid (BON) tumors xenotransplanted into athymic nude mice. In the present study, however, SMS 201-995 did not inhibit in vitro growth of BON cells, but rather SMS 201-995 stimulated growth in a dose-dependent fashion. The growth-stimulatory effect was likely mediated through the reduction of cyclic AMP production. Unsuccessful treatment of certain types of carcinoid tumor with SMS 201-995 may be partly due to the direct growth-stimulatory effect of SMS 201-995 on carcinoid cells.

Original languageEnglish (US)
Pages (from-to)577-581
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume185
Issue number2
DOIs
StatePublished - Jun 15 1992

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Octreotide
Carcinoid Tumor
Somatostatin
Tumors
Growth
Nude Mice
Cyclic AMP

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Unexpected growth-stimulatory effect of somatostatin analogue on cultured human pancreatic carcinoid cells. / Ishizuka, Jin; Beauchamp, R. Daniel; Evers, B. Mark; Townsend, Courtney; Thompson, James C.

In: Biochemical and Biophysical Research Communications, Vol. 185, No. 2, 15.06.1992, p. 577-581.

Research output: Contribution to journalArticle

Ishizuka, Jin ; Beauchamp, R. Daniel ; Evers, B. Mark ; Townsend, Courtney ; Thompson, James C. / Unexpected growth-stimulatory effect of somatostatin analogue on cultured human pancreatic carcinoid cells. In: Biochemical and Biophysical Research Communications. 1992 ; Vol. 185, No. 2. pp. 577-581.
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