Unexpected growth-stimulatory effect of somatostatin analogue on cultured human pancreatic carcinoid cells

Jin Ishizuka, R. Daniel Beauchamp, B. Mark Evers, Courtney M. Townsend, James C. Thompson

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Therapeutic efficacy of a synthetic somatostatin analogue for the treatment of carcinoid tumors is still controversial. In vivo studies performed in our laboratory showed that a somatostatin analogue, SMS 201-995, significantly inhibited growth of human pancreatic carcinoid (BON) tumors xenotransplanted into athymic nude mice. In the present study, however, SMS 201-995 did not inhibit in vitro growth of BON cells, but rather SMS 201-995 stimulated growth in a dose-dependent fashion. The growth-stimulatory effect was likely mediated through the reduction of cyclic AMP production. Unsuccessful treatment of certain types of carcinoid tumor with SMS 201-995 may be partly due to the direct growth-stimulatory effect of SMS 201-995 on carcinoid cells.

Original languageEnglish (US)
Pages (from-to)577-581
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume185
Issue number2
DOIs
StatePublished - Jun 15 1992

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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