Unilateral multiple facial nerve branch reconstruction using "end-to-side loop graft" supercharged by hypoglossal nerve

Hajime Matsumine, Ryo Sasaki, Yuichi Takeuchi, Yorikatsu Watanabe, Yosuke Niimi, Hiroyuki Sakurai, Mariko Miyata, Masayuki Yamato

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Extensive facial nerve defects between the facial nerve trunk and its branches can be clinically reconstructed by incorporating double innervation into an end-to-side loop graft technique. This study developed a new animal model to evaluate the technique's ability to promote nerve regeneration. Methods: Rats were divided into the intact, nonsupercharge, and supercharge groups. Artificially created facial nerve defects were reconstructed with a nerve graft, which was end-to-end sutured from proximal facial nerve stump to the mandibular branch (nonsupercharge group), or with the graft of which other end was end-to-side sutured to the hypoglossal nerve (supercharge group). And they were evaluated after 30 weeks. Results: Axonal diameter was significantly larger in the supercharge group than in the nonsupercharge group for the buccal (3.78 ± 1.68 vs 3.16 ± 1.22; P < 0.0001) and marginal mandibular branches (3.97 ± 2.31 vs 3.46 ± 1.57; P < 0.0001), but the diameter was significantly larger in the intact group for all branches except the temporal branch. In the supercharge group, compound muscle action potential amplitude was significantly higher than in the nonsupercharge group (4.18 ± 1.49 mV vs 1.87 ± 0.37 mV; P < 0.0001) and similar to that in the intact group (4.11 ± 0.68 mV). Retrograde labeling showed that the mimetic muscles were double-innervated by facial and hypoglossal nerve nuclei in the supercharge group. Conclusions: Multiple facial nerve branch reconstruction with an endto-side loop graft was able to achieve axonal distribution. Additionally, axonal supercharge from the hypoglossal nerve significantly improved outcomes.

Original languageEnglish (US)
Article number206
JournalPlastic and Reconstructive Surgery - Global Open
Volume2
Issue number10
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

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Hypoglossal Nerve
Facial Nerve
Transplants
Facial Muscles
Nerve Regeneration
Cheek
Action Potentials
Animal Models
Muscles

ASJC Scopus subject areas

  • Surgery

Cite this

Unilateral multiple facial nerve branch reconstruction using "end-to-side loop graft" supercharged by hypoglossal nerve. / Matsumine, Hajime; Sasaki, Ryo; Takeuchi, Yuichi; Watanabe, Yorikatsu; Niimi, Yosuke; Sakurai, Hiroyuki; Miyata, Mariko; Yamato, Masayuki.

In: Plastic and Reconstructive Surgery - Global Open, Vol. 2, No. 10, 206, 01.01.2014.

Research output: Contribution to journalArticle

Matsumine, Hajime ; Sasaki, Ryo ; Takeuchi, Yuichi ; Watanabe, Yorikatsu ; Niimi, Yosuke ; Sakurai, Hiroyuki ; Miyata, Mariko ; Yamato, Masayuki. / Unilateral multiple facial nerve branch reconstruction using "end-to-side loop graft" supercharged by hypoglossal nerve. In: Plastic and Reconstructive Surgery - Global Open. 2014 ; Vol. 2, No. 10.
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