Unique patterns of androgen regulation of the expression of two genes in murine kidney

J. F. Catterall, C. S. Watson, B. Funkenstein

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The kidneys of androgen stimulated mice exhibit a hypertrophic response but no hyperplasia or concomitant DNA replication. Androgens increase the expression of several genes in mouse kidney. The response of the (β-glucuronidase gene to testosterone in this tissue is characterized by a 1-2 day lag and relatively slow induction kinetics. The gene coding for kidney androgen-regulated protein (KAP) exhibits quite a different response to the hormone when compared on the basis of initial response to a given dose, dose required to produce maximal response, and apparent sensitivity to low levels of androgen-receptor complexes in renal nuclei. The analysis of the accumulation of the mRNAs produced by these two genes suggests that gene-specific differential sensitivity to androgen receptor complexes governs the development of the cellular male phenotype in this tissue.

Original languageEnglish (US)
Pages (from-to)193-199
Number of pages7
JournalJournal of Steroid Biochemistry
Volume27
Issue number1-3
DOIs
StatePublished - 1987
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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