Unique patterns of androgen regulation of the expression of two genes in murine kidney

J. F. Catterall; C. S. Watson; B. Funkenstein

doi:10.1016/0022-4731(87)90310-4

Unique patterns of androgen regulation of the expression of two genes in murine kidney

J. F. Catterall
, C. S. Watson
, B. Funkenstein

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The kidneys of androgen stimulated mice exhibit a hypertrophic response but no hyperplasia or concomitant DNA replication. Androgens increase the expression of several genes in mouse kidney. The response of the (β-glucuronidase gene to testosterone in this tissue is characterized by a 1-2 day lag and relatively slow induction kinetics. The gene coding for kidney androgen-regulated protein (KAP) exhibits quite a different response to the hormone when compared on the basis of initial response to a given dose, dose required to produce maximal response, and apparent sensitivity to low levels of androgen-receptor complexes in renal nuclei. The analysis of the accumulation of the mRNAs produced by these two genes suggests that gene-specific differential sensitivity to androgen receptor complexes governs the development of the cellular male phenotype in this tissue.

Original language	English (US)
Pages (from-to)	193-199
Number of pages	7
Journal	Journal of Steroid Biochemistry
Volume	27
Issue number	1-3
DOIs	https://doi.org/10.1016/0022-4731(87)90310-4
State	Published - 1987
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Endocrinology

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10.1016/0022-4731(87)90310-4

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title = "Unique patterns of androgen regulation of the expression of two genes in murine kidney",

abstract = "The kidneys of androgen stimulated mice exhibit a hypertrophic response but no hyperplasia or concomitant DNA replication. Androgens increase the expression of several genes in mouse kidney. The response of the (β-glucuronidase gene to testosterone in this tissue is characterized by a 1-2 day lag and relatively slow induction kinetics. The gene coding for kidney androgen-regulated protein (KAP) exhibits quite a different response to the hormone when compared on the basis of initial response to a given dose, dose required to produce maximal response, and apparent sensitivity to low levels of androgen-receptor complexes in renal nuclei. The analysis of the accumulation of the mRNAs produced by these two genes suggests that gene-specific differential sensitivity to androgen receptor complexes governs the development of the cellular male phenotype in this tissue.",

author = "Catterall, \{J. F.\} and Watson, \{C. S.\} and B. Funkenstein",

note = "Funding Information: Acknowledgemen\&-The authors wisht o thankM S Jean Schweis for preparation of the manuscript. This work was supported by NIH grant number HD-I 3541.",

year = "1987",

doi = "10.1016/0022-4731(87)90310-4",

language = "English (US)",

volume = "27",

pages = "193--199",

journal = "Journal of Steroid Biochemistry",

issn = "0022-4731",

publisher = "Elsevier Ltd",

number = "1-3",

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TY - JOUR

T1 - Unique patterns of androgen regulation of the expression of two genes in murine kidney

AU - Catterall, J. F.

AU - Watson, C. S.

AU - Funkenstein, B.

N1 - Funding Information: Acknowledgemen&-The authors wisht o thankM S Jean Schweis for preparation of the manuscript. This work was supported by NIH grant number HD-I 3541.

PY - 1987

Y1 - 1987

N2 - The kidneys of androgen stimulated mice exhibit a hypertrophic response but no hyperplasia or concomitant DNA replication. Androgens increase the expression of several genes in mouse kidney. The response of the (β-glucuronidase gene to testosterone in this tissue is characterized by a 1-2 day lag and relatively slow induction kinetics. The gene coding for kidney androgen-regulated protein (KAP) exhibits quite a different response to the hormone when compared on the basis of initial response to a given dose, dose required to produce maximal response, and apparent sensitivity to low levels of androgen-receptor complexes in renal nuclei. The analysis of the accumulation of the mRNAs produced by these two genes suggests that gene-specific differential sensitivity to androgen receptor complexes governs the development of the cellular male phenotype in this tissue.

AB - The kidneys of androgen stimulated mice exhibit a hypertrophic response but no hyperplasia or concomitant DNA replication. Androgens increase the expression of several genes in mouse kidney. The response of the (β-glucuronidase gene to testosterone in this tissue is characterized by a 1-2 day lag and relatively slow induction kinetics. The gene coding for kidney androgen-regulated protein (KAP) exhibits quite a different response to the hormone when compared on the basis of initial response to a given dose, dose required to produce maximal response, and apparent sensitivity to low levels of androgen-receptor complexes in renal nuclei. The analysis of the accumulation of the mRNAs produced by these two genes suggests that gene-specific differential sensitivity to androgen receptor complexes governs the development of the cellular male phenotype in this tissue.

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DO - 10.1016/0022-4731(87)90310-4

M3 - Article

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AN - SCOPUS:0023543712

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VL - 27

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JO - Journal of Steroid Biochemistry

JF - Journal of Steroid Biochemistry

IS - 1-3

ER -

Unique patterns of androgen regulation of the expression of two genes in murine kidney

Abstract

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