Unraveling myasthenia gravis immunopathogenesis using animal models

Erdem Tüzün; Premkumar Christadoss

doi:10.1016/j.ddmod.2006.03.013

Unraveling myasthenia gravis immunopathogenesis using animal models

Erdem Tüzün
, Premkumar Christadoss

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Experimental autoimmune myasthenia gravis (EAMG), induced by immunization of animals with acetylcholine receptor, has proven to be a valuable model to understand the immunological and molecular aspects of autoimmune myasthenia gravis (MG) pathogenesis. Availability of knockout and transgenic mice has enabled the investigation of the significance of various immunological factors in MG pathogenesis. EAMG model also provides researchers a practical tool to test the efficacy of potential treatment methods for MG and for other autoimmune diseases.

Original language	English (US)
Pages (from-to)	15-20
Number of pages	6
Journal	Drug Discovery Today: Disease Models
Volume	3
Issue number	1
DOIs	https://doi.org/10.1016/j.ddmod.2006.03.013
State	Published - 2006
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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10.1016/j.ddmod.2006.03.013

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abstract = "Experimental autoimmune myasthenia gravis (EAMG), induced by immunization of animals with acetylcholine receptor, has proven to be a valuable model to understand the immunological and molecular aspects of autoimmune myasthenia gravis (MG) pathogenesis. Availability of knockout and transgenic mice has enabled the investigation of the significance of various immunological factors in MG pathogenesis. EAMG model also provides researchers a practical tool to test the efficacy of potential treatment methods for MG and for other autoimmune diseases.",

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AU - Tüzün, Erdem

AU - Christadoss, Premkumar

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AB - Experimental autoimmune myasthenia gravis (EAMG), induced by immunization of animals with acetylcholine receptor, has proven to be a valuable model to understand the immunological and molecular aspects of autoimmune myasthenia gravis (MG) pathogenesis. Availability of knockout and transgenic mice has enabled the investigation of the significance of various immunological factors in MG pathogenesis. EAMG model also provides researchers a practical tool to test the efficacy of potential treatment methods for MG and for other autoimmune diseases.

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U2 - 10.1016/j.ddmod.2006.03.013

DO - 10.1016/j.ddmod.2006.03.013

M3 - Review article

AN - SCOPUS:33645879218

SN - 1740-6757

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EP - 20

JO - Drug Discovery Today: Disease Models

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ER -

Unraveling myasthenia gravis immunopathogenesis using animal models

Abstract

ASJC Scopus subject areas

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