Unrecognized spotted fever group rickettsiosis masquerading as dengue fever in Mexico

Jorge E. Zavala-Velazquez, Xue Jie Yu, David Walker

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Although Rocky Mountain spotted fever was documented in northern Mexico during the 1940s, spotted lever group (SFG) rickettsioses have subsequently received little attention in Mexico. In this study, sera collected in 1993 from 50 patients from the Mexican states of Yucatan and Jalisco, who were suspected clinically to have dengue fever but had no antibodies to dengue virus, were examined by indirect immunofluorescence for IgM antibodies reactive with Rickettsia rickettsii, R. akari, and R. typhi. Twenty (40%) of the patients' sera contained IgM antibodies to SFG rickettsiae at a titer of 128 or greater. Among five sera reactive only against R. akari, four were from patients in Jalisco where a cluster of cases occurred in June and July. Among five sera reactive only with R. rickettsii, all were from Yucatan patients. Sera of 10 patients contained antibodies reactive with antigens shared by R. rickettsii and R. akari. The clinical signs and symptoms (fever, 100%; myalgia, 95%; headache, 85%; rash, 85%) were similar to those of dengue fever patients identified in this study. However, the incidence of rash was substantially higher than the nondengue, nonrickettsiosis patients. One or more SFG rickettsioses appear to be present in areas of Mexico not previously recognized to harbor these organisms. The etiologic agent or agents are as yet unknown.

Original languageEnglish (US)
Pages (from-to)157-159
Number of pages3
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume55
Issue number2
StatePublished - 1996

Fingerprint

Dengue
Mexico
Fever
Rickettsia rickettsii
Serum
Antibodies
Exanthema
Immunoglobulin M
Rocky Mountain Spotted Fever
Rickettsia
Dengue Virus
Myalgia
Indirect Fluorescent Antibody Technique
Signs and Symptoms
Headache
Antigens
Incidence

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Unrecognized spotted fever group rickettsiosis masquerading as dengue fever in Mexico. / Zavala-Velazquez, Jorge E.; Yu, Xue Jie; Walker, David.

In: American Journal of Tropical Medicine and Hygiene, Vol. 55, No. 2, 1996, p. 157-159.

Research output: Contribution to journalArticle

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