Unusual clinical manifestations of dengue disease – Real or imagined?

Cássia Fernanda Estofolete, Mânlio Tasso de Oliveira Mota, Ana Carolina Bernardes Terzian, Bruno Henrique Gonçalves de Aguiar Milhim, Milene Rocha Ribeiro, Delzi Vinha Nunes, Maria Paula Mourão, Shannan Rossi, Mauricio Lacerda Nogueira, Nikos Vasilakis

Research output: Contribution to journalReview article

Abstract

The disease caused by each of the four serotypes of dengue virus (DENV) have plagued humans since last century. Symptoms of dengue virus (DENV) infection range from asymptomatic to dengue fever (DF) to severe dengue disease (SDD). One third of the world's population lives in regions with active urban DENV transmission, and thousands of serologically naïve travelers visit these areas annually, making a significant portion of the human population at risk of being infected. Even though lifelong immunity to the homotypic serotype is achieved after a primary DENV infection. Heterotypic DENV infections may be exacerbated by a pre-existing immune memory to the primary infection and can result in an increased probability of severe disease. Not only, age, comorbidities and presence of antibodies transferred passively from dengue-immune mother to infants are considered risk factors to dengue severe forms. Plasma leakage and multiple organ impairment are well documented in the literature, affecting liver, lung, brain, muscle, and kidney. However, unusual manifestation, severe or not, have been reported and may require medical attention. This review will summarize and discuss the increasing reports of unusual manifestations in the clinical course of dengue infection.

Original languageEnglish (US)
Article number105134
JournalActa Tropica
Volume199
DOIs
StatePublished - Nov 1 2019

Fingerprint

Dengue Virus
Dengue
Virus Diseases
Severe Dengue
Infection
Comorbidity
Immunity
Mothers
Kidney
Muscles
Lung
Antibodies
Liver
Brain
Population

Keywords

  • Arbovirus
  • Clinical manifestations
  • Dengue
  • Neurologic complications

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Estofolete, C. F., de Oliveira Mota, M. T., Bernardes Terzian, A. C., de Aguiar Milhim, B. H. G., Ribeiro, M. R., Nunes, D. V., ... Vasilakis, N. (2019). Unusual clinical manifestations of dengue disease – Real or imagined? Acta Tropica, 199, [105134]. https://doi.org/10.1016/j.actatropica.2019.105134

Unusual clinical manifestations of dengue disease – Real or imagined? / Estofolete, Cássia Fernanda; de Oliveira Mota, Mânlio Tasso; Bernardes Terzian, Ana Carolina; de Aguiar Milhim, Bruno Henrique Gonçalves; Ribeiro, Milene Rocha; Nunes, Delzi Vinha; Mourão, Maria Paula; Rossi, Shannan; Nogueira, Mauricio Lacerda; Vasilakis, Nikos.

In: Acta Tropica, Vol. 199, 105134, 01.11.2019.

Research output: Contribution to journalReview article

Estofolete, CF, de Oliveira Mota, MT, Bernardes Terzian, AC, de Aguiar Milhim, BHG, Ribeiro, MR, Nunes, DV, Mourão, MP, Rossi, S, Nogueira, ML & Vasilakis, N 2019, 'Unusual clinical manifestations of dengue disease – Real or imagined?', Acta Tropica, vol. 199, 105134. https://doi.org/10.1016/j.actatropica.2019.105134
Estofolete CF, de Oliveira Mota MT, Bernardes Terzian AC, de Aguiar Milhim BHG, Ribeiro MR, Nunes DV et al. Unusual clinical manifestations of dengue disease – Real or imagined? Acta Tropica. 2019 Nov 1;199. 105134. https://doi.org/10.1016/j.actatropica.2019.105134
Estofolete, Cássia Fernanda ; de Oliveira Mota, Mânlio Tasso ; Bernardes Terzian, Ana Carolina ; de Aguiar Milhim, Bruno Henrique Gonçalves ; Ribeiro, Milene Rocha ; Nunes, Delzi Vinha ; Mourão, Maria Paula ; Rossi, Shannan ; Nogueira, Mauricio Lacerda ; Vasilakis, Nikos. / Unusual clinical manifestations of dengue disease – Real or imagined?. In: Acta Tropica. 2019 ; Vol. 199.
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