@article{604b1094be87466ba4c17eed423c82e0,
title = "Unveiling molecular signatures of preeclampsia and gestational diabetes mellitus with multi-omics and innovative cheminformatics visualization tools",
abstract = "To fully enable the development of diagnostic tools and progressive pharmaceutical drugs, it is imperative to understand the molecular changes occurring before and during disease onset and progression. Systems biology assessments utilizing multi-omic analyses (e.g. the combination of proteomics, lipidomics, genomics, etc.) have shown enormous value in determining molecules prevalent in diseases and their associated mechanisms. Herein, we utilized multi-omic evaluations, multi-dimensional analysis methods, and new cheminformatics-based visualization tools to provide an in depth understanding of the molecular changes taking place in preeclampsia (PRE) and gestational diabetes mellitus (GDM) patients. Since PRE and GDM are two prevalent pregnancy complications that result in adverse health effects for both the mother and fetus during pregnancy and later in life, a better understanding of each is essential. The multi-omic evaluations performed here provide new insight into the end-stage molecular profiles of each disease, thereby supplying information potentially crucial for earlier diagnosis and treatments.",
author = "Odenkirk, {Melanie T.} and Stratton, {Kelly G.} and Gritsenko, {Marina A.} and Bramer, {Lisa M.} and Webb-Robertson, {Bobbie Jo M.} and Bloodsworth, {Kent J.} and Weitz, {Karl K.} and Lipton, {Anna K.} and Monroe, {Matthew E.} and Ash, {Jeremy R.} and Denis Fourches and Taylor, {Brandie D.} and Burnum-Johnson, {Kristin E.} and Baker, {Erin S.}",
note = "Funding Information: Portions of this research were supported by grants from the NIH National Institute of Environmental Health Sciences (P30ES025128, P42 ES027704 and P42ES031009), startup funds from North Carolina State University, the NIH Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R21 HD084788, and the Discovery Foundation Grant. This data was collected in the W. R. Wiley Environmental Molecular Sciences Laboratory (EMSL) (grid.436923.9), a DOE Office of Science User Facility sponsored by the Office of Biological and Environmental Research and located at Pacific Northwest National Laboratory (PNNL). PNNL is a multiprogram national laboratory operated by Battelle for the Department of Energy (DOE) under Contract DE-AC05-76RLO 1830. Publisher Copyright: {\textcopyright} 2020 The Royal Society of Chemistry.",
year = "2020",
month = dec,
doi = "10.1039/d0mo00074d",
language = "English (US)",
volume = "16",
pages = "521--532",
journal = "Molecular Omics",
issn = "2515-4184",
publisher = "Royal Society of Chemistry",
number = "6",
}