Update 1 of: Recent progress in development of dopamine receptor subtype-selective agents: Potential therapeutics for neurological and psychiatric disorders

Na Ye, John L. Neumeyer, Ross J. Baldessarini, Xuechu Zhen, Ao Zhang

Research output: Contribution to journalReview article

56 Citations (Scopus)

Abstract

Dopamine (DA) is a critical neurotransmitter in the mammalian central nervous system (CNS). The cerebral dopaminergic system is implicated in the pathophysiology of several neurobehavioral disorders, including Parkinson's disease and other movement and hyperactivity disorders. The mesocortical system is a neural pathway connecting the ventral tegmentum of midbrain to the cerebral cortex, particularly the mesioprefontal lobes. It is essential to the normal cognitive function of the dorsolateral prefrontal cortex and involved in motivation and emotional response. The mesolimbic system is one of the neural pathways in the brain linking the ventral tegmental area (VTA) to the nucleus accumbens septi (NAS) in the limbic system. DA receptors belong to a superfamily of large proteins characterized by having seven relatively hydrophobic segments that are assumed to be cell-membrane spanning. They are coupled to G proteins that interact with several membrane or cytoplasmic effector molecules (usually enzymes, transporters, or ion channels) that regulate neuronal functions.

Original languageEnglish (US)
JournalChemical Reviews
Volume113
Issue number5
DOIs
StatePublished - May 8 2013
Externally publishedYes

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Dopamine Receptors
Neurology
Cell membranes
Ion Channels
GTP-Binding Proteins
Neurotransmitter Agents
Dopamine
Brain
Membranes
Molecules
Enzymes
Proteins
Psychiatry

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Update 1 of : Recent progress in development of dopamine receptor subtype-selective agents: Potential therapeutics for neurological and psychiatric disorders. / Ye, Na; Neumeyer, John L.; Baldessarini, Ross J.; Zhen, Xuechu; Zhang, Ao.

In: Chemical Reviews, Vol. 113, No. 5, 08.05.2013.

Research output: Contribution to journalReview article

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