TY - JOUR
T1 - Update in autoimmune and paraneoplastic myelopathies
T2 - Newly described antigen targets and antibody testing
AU - Passeri, Michlene
AU - Matthews, Elizabeth
AU - Kammeyer, Ryan
AU - Piquet, Amanda L.
N1 - Publisher Copyright:
Copyright © 2022 Passeri, Matthews, Kammeyer and Piquet.
PY - 2022/7/28
Y1 - 2022/7/28
N2 - Myelopathy is an increasingly recognized presentation of many antibody-mediated neuroinflammatory disorders. While specific features of certain autoimmune myelopathies such as aquaporin-4 antibody associated neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein associated disorder (MOGAD) are well-characterized, other less commonly seen antibody-associated myelopathies are not as well-defined. These include but are not limited to, Hu/ANNA1, anti-glial fibrillary acidic protein (GFAP), anti-CV2/collapsin response mediator protein (CRMP5), and amphiphysin. Here, we review the mentioned more common antibody mediated myelopathies as well those that as less common, followed by a review of differentials that may mimic these disorders.
AB - Myelopathy is an increasingly recognized presentation of many antibody-mediated neuroinflammatory disorders. While specific features of certain autoimmune myelopathies such as aquaporin-4 antibody associated neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein associated disorder (MOGAD) are well-characterized, other less commonly seen antibody-associated myelopathies are not as well-defined. These include but are not limited to, Hu/ANNA1, anti-glial fibrillary acidic protein (GFAP), anti-CV2/collapsin response mediator protein (CRMP5), and amphiphysin. Here, we review the mentioned more common antibody mediated myelopathies as well those that as less common, followed by a review of differentials that may mimic these disorders.
KW - autoimmune manifestations
KW - MOG antibody associated diseases
KW - myelitis
KW - myelopathy
KW - NMO spectrum disorder (NMOSD)
KW - paraneoplastic syndrome (PNS)
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U2 - 10.3389/fneur.2022.972143
DO - 10.3389/fneur.2022.972143
M3 - Review article
AN - SCOPUS:85135938118
SN - 1664-2295
VL - 13
JO - Frontiers in Neurology
JF - Frontiers in Neurology
M1 - 972143
ER -